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周围神经场刺激疗法治疗胸痛患者:一项前瞻性研究。

Peripheral Nerve Field Stimulation Therapy for Patients With Thoracic Pain: A Prospective Study.

作者信息

Mitchell Bruce, Verrills Paul, Vivian David, DuToit Neels, Barnard Adele, Sinclair Chantelle

机构信息

Monash House, Clayton, Victoria, Australia.

出版信息

Neuromodulation. 2016 Oct;19(7):752-759. doi: 10.1111/ner.12458. Epub 2016 Jul 4.

Abstract

OBJECTIVE

Relative to the number of patients suffering chronic lumbar and cervical pain, fewer patients suffer persistent thoracic pain. Consequently there is less literature, with smaller sample sizes, reporting treatment of this cohort. Here, we assess peripheral nerve field stimulation (PNfS) as a potential treatment for chronic thoracic pain.

MATERIALS AND METHODS

This study included 20 consecutive chronic thoracic pain sufferers that responded successfully to PNfS trial. The patients were subsequently implanted with permanent eight-contact electrode linear percutaneous leads within their major area of pain. Patients were followed up at 12 months for outcome reporting. All 20 patients were considered in the statistical analysis, despite removal of three devices prior to follow up.

RESULTS

The average baseline pre-treatment Numerical Pain Rating Scale (NPRS) score was 7.75 ± 1.4. Following PNfS, the mean NPRS score was 2.25 ±2.14, reflecting a significant average improvement of 5.5 ± 3.31. Three patients were explanted prior to follow up: the first gained excellent thoracic pain relief but pain at the Implantable Pulse Generator (IPG) site could not be overcome, the second achieved excellent pain relief but the PNfS was removed due to recurrent infection and in the final instance, the intervention offered only poor relief and the device removed.

CONCLUSION

PNfS is an effective intervention for intractable disabling thoracic pain, offering sustained and worthwhile pain relief, for the overwhelming majority of the cohort. This may be especially true when considering a combined treatment approach of PNfS and analgesic use to manage remnant pain.

摘要

目的

相对于患有慢性腰颈疼痛的患者数量,患有持续性胸痛的患者较少。因此,关于这一群体治疗的文献较少,样本量也较小。在此,我们评估外周神经场刺激(PNfS)作为慢性胸痛的一种潜在治疗方法。

材料与方法

本研究纳入了20例连续的慢性胸痛患者,他们对PNfS试验反应成功。随后,在患者主要疼痛区域植入永久性八触点电极线性经皮导线。对患者进行了12个月的随访以报告结果。尽管在随访前移除了3个装置,但在统计分析中仍纳入了所有20例患者。

结果

治疗前数字疼痛评分量表(NPRS)的平均基线评分为7.75±1.4。PNfS治疗后,NPRS平均评分为2.25±2.14,平均改善显著,为5.5±3.31。3例患者在随访前被取出装置:第一例患者胸部疼痛得到了极好的缓解,但植入式脉冲发生器(IPG)部位的疼痛无法消除;第二例患者疼痛得到了极好的缓解,但由于反复感染而移除了PNfS;最后一例患者干预效果不佳,装置被移除。

结论

对于绝大多数患者而言,PNfS是一种治疗顽固性致残性胸痛的有效干预措施,能提供持续且有价值的疼痛缓解。当考虑采用PNfS与使用镇痛药相结合的治疗方法来处理残余疼痛时,情况可能尤其如此。

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