Department of Pediatric Medicine, IPGMER and SSKM Hospital, Kolkata, India.
Indian Pediatr. 2011 Sep;48(9):735-6.
Diabetic ketoacidosisis as a complication of L-asparaginase therapy in children with acute leukemia is rare. Hyperglycemia may occur in about 10% of cases receiving Lasp, which may present as mild glucose intolerance to severe hyperglycemia. We report two children with acute lymphoblastic leukemia who developed diabetic ketoacidosis after treatment with L-asparaginase.
糖尿病酮症酸中毒是儿童急性白血病接受 L-天冬酰胺酶治疗的一种罕见并发症。约 10%接受 Lasp 治疗的患者会出现高血糖,表现为轻度葡萄糖耐量异常到重度高血糖。我们报告了 2 例接受 L-天冬酰胺酶治疗后发生糖尿病酮症酸中毒的急性淋巴细胞白血病患儿。