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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Yamamoto H, Kanaide H

Medical Education Center, Kyushu University, Fukuoka, Japan.

Gen Pharmacol. 1990;21(4):387-93. doi: 10.1016/0306-3623(90)90686-g.

Inositol 1,4,5-trisphosphate (I(1,4,5)P3) releases Ca2+ from ATP-dependent Ca2+ stores in permeabilized cells and in microsomal fractions. 2. Various factors affect the amount of Ca2+ released by I(1,4,5)P3. 3. The molecular mechanism involved in the I(1,4,5)P3-induced Ca2+ release is now being investigated and I(1,4,5)P3-specific receptors and/or specific release channels are being given special attention. 4. While the I(1,4,5)P3-sensitive Ca2+ stores are presumed to locate at the endoplasmic reticulum, the relation between the I(1,4,5)P3- and the agonist-sensitive Ca2+ stores remains to be elucidated.

肌醇1,4,5 -三磷酸（I(1,4,5)P3）可使通透细胞和微粒体组分中依赖ATP的钙储存释放Ca2+。2. 多种因素影响I(1,4,5)P3释放Ca2+的量。3. 目前正在研究I(1,4,5)P3诱导Ca2+释放所涉及的分子机制，I(1,4,5)P3特异性受体和/或特异性释放通道受到特别关注。4. 虽然推测I(1,4,5)P3敏感的钙储存位于内质网，但I(1,4,5)P3与激动剂敏感的钙储存之间的关系仍有待阐明。

Yamamoto H, Kanaide H

Medical Education Center, Kyushu University, Fukuoka, Japan.

Gen Pharmacol. 1990;21(4):387-93. doi: 10.1016/0306-3623(90)90686-g.

Inositol 1,4,5-trisphosphate (I(1,4,5)P3) releases Ca2+ from ATP-dependent Ca2+ stores in permeabilized cells and in microsomal fractions. 2. Various factors affect the amount of Ca2+ released by I(1,4,5)P3. 3. The molecular mechanism involved in the I(1,4,5)P3-induced Ca2+ release is now being investigated and I(1,4,5)P3-specific receptors and/or specific release channels are being given special attention. 4. While the I(1,4,5)P3-sensitive Ca2+ stores are presumed to locate at the endoplasmic reticulum, the relation between the I(1,4,5)P3- and the agonist-sensitive Ca2+ stores remains to be elucidated.

肌醇1,4,5 -三磷酸（I(1,4,5)P3）可使通透细胞和微粒体组分中依赖ATP的钙储存释放Ca2+。2. 多种因素影响I(1,4,5)P3释放Ca2+的量。3. 目前正在研究I(1,4,5)P3诱导Ca2+释放所涉及的分子机制，I(1,4,5)P3特异性受体和/或特异性释放通道受到特别关注。4. 虽然推测I(1,4,5)P3敏感的钙储存位于内质网，但I(1,4,5)P3与激动剂敏感的钙储存之间的关系仍有待阐明。