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The specific GTP requirement for inositol 1,4,5-trisphosphate-induced Ca2+ release from skinned vascular smooth muscle.

作者信息

Saida K, Twort C, van Breemen C

机构信息

Department of Pharmacology, University of Miami, School of Medicine, FL 33101.

出版信息

J Cardiovasc Pharmacol. 1988;12 Suppl 5:S47-50.

PMID:2469878
Abstract

Exogenous GTP was required for the induction of Ca2+ release from smooth muscle SR by IP3 if endogenous GTP was depleted. NaN3 could function as a partial substitute for GTP as a cofactor for the IP3-induced Ca2+ release from the SR. In contrast to the IP3-induced Ca2+ release, caffeine-induced Ca2+ release from the SR did not require GTP. Pertussis toxin inhibited the IP3-induced Ca2+ release from the SR, whereas it had no effect on caffeine-induced Ca2+ release. These results indicate that in smooth muscle two different Ca2+ release-channels exist in the SR: (a) activated by IP3, and (b) activated by caffeine or Ca2+.

摘要

相似文献

1
The specific GTP requirement for inositol 1,4,5-trisphosphate-induced Ca2+ release from skinned vascular smooth muscle.
J Cardiovasc Pharmacol. 1988;12 Suppl 5:S47-50.
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引用本文的文献

1
A slowly ADP-ribosylated pertussis-toxin-sensitive GTP-binding regulatory protein is required for vasopressin-stimulated Ca2+ inflow in hepatocytes.血管加压素刺激肝细胞Ca2+内流需要一种缓慢的ADP核糖基化的百日咳毒素敏感的GTP结合调节蛋白。
Biochem J. 1994 Apr 15;299 ( Pt 2)(Pt 2):399-407. doi: 10.1042/bj2990399.
2
Inositol trisphosphate enhances Ca2+ oscillations but not Ca(2+)-induced Ca2+ release from cardiac sarcoplasmic reticulum.肌醇三磷酸增强钙离子振荡，但不增强心脏肌浆网中钙离子诱导的钙离子释放。
Pflugers Arch. 1991 Mar;418(1-2):1-6. doi: 10.1007/BF00370444.
3
GTP and noradrenaline-induced force in isolated toxin-permeabilized rat anococcygeus and guinea-pig portal vein.
鸟苷三磷酸（GTP）和去甲肾上腺素对离体毒素通透处理的大鼠肛门尾骨肌及豚鼠门静脉所诱导的张力
J Physiol. 1991 Jun;437:543-61. doi: 10.1113/jphysiol.1991.sp018610.