Argov Z, Mastaglia F L
Br Med J. 1979 Mar 10;1(6164):663-6. doi: 10.1136/bmj.1.6164.663.
Review of the various drugs in current clinical use showed that over 50 of them may cause a purely sensory or mixed sensorimotor neuropathy. These include antimicrobials, such as isoniazid, ethambutol, ethionamide, nitrofurantoin, and metronidazole; antineoplastic agents, particularly vinca alkaloids; cardiovascular drugs, such as perhexiline and hydrallazine; hypnotics and psychotropics, notable methaqualone; antirheumatics, such as gold, indomethacin, and chloroquine; anticonvulsants, particularly phenytoin; and other drugs, including disulfiram, calcium carbimide, and dapsone. Patients receiving drug treatment who complain of paraesthesie, pain, muscle cramps, or other abnormal sensations and those without symptoms who are receiving drugs that are known or suspected to be neurotoxic should undergo neurological examination and studies of motor and sensory nerve conduction. This will allow the incidence of drug-induced peripheral neuropathy to be determined more precisely.
对当前临床使用的各种药物进行审查发现，其中50多种药物可能导致单纯性感觉或混合性感觉运动神经病变。这些药物包括抗菌药，如异烟肼、乙胺丁醇、乙硫异烟胺、呋喃妥因和甲硝唑；抗肿瘤药，特别是长春花生物碱；心血管药物，如哌克昔林和肼屈嗪；催眠药和精神药物，尤其是甲喹酮；抗风湿药，如金制剂、吲哚美辛和氯喹；抗惊厥药，特别是苯妥英；以及其他药物，包括双硫仑、卡马咪嗪和氨苯砜。接受药物治疗且主诉感觉异常、疼痛、肌肉痉挛或其他异常感觉的患者，以及正在接受已知或怀疑具有神经毒性药物治疗但无症状的患者，应接受神经系统检查以及运动和感觉神经传导研究。这将更精确地确定药物性周围神经病的发生率。
