Bio-X Center and Affiliated Changning Mental Health Center, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai 200030, PR China.
Prog Neuropsychopharmacol Biol Psychiatry. 2012 Jan 10;36(1):17-21. doi: 10.1016/j.pnpbp.2011.09.011. Epub 2011 Oct 2.
Neuregulin-1 (NRG1) is associated with schizophrenia. As one of the receptors of NRG1, v-erb-a erythroblastic leukemia viral oncogene homolog 4 (ErbB4) has also been reported to be associated with schizophrenia. Since there can be shared genetic variants among bipolar affective disorder, major depressive disorder and schizophrenia, we tested the association between ErbB4 and these three major psychiatric disorders in the Han Chinese population. Five single nucleotide polymorphisms (SNPs) were selected based on previous positive reports and linkage disequilibrium information of the HapMap Han Chinese individuals from Beijing (CHB)+individuals from Tokyo, Japan (JPT) population. These SNPs were genotyped in 1140 bipolar affective disorder (BPAD) patients, 1140 schizophrenia (SCZ) patients, 1139 major depressive disorder (MDD) patients and 1140 normal controls. Two SNPs (rs707284 and rs839523) showed nominal significance in the BPAD patients but this was eliminated after permutation. No significant association between ErbB4 and the two other psychiatric disorders was observed, nor did haplotype analysis reveal any positive signal.
神经调节蛋白 1（NRG1）与精神分裂症有关。NRG1 的一种受体 v-erb-a 红细胞白血病病毒致癌基因同源物 4（ErbB4）也与精神分裂症有关。由于双相情感障碍、重度抑郁症和精神分裂症之间可能存在共同的遗传变异，我们在汉族人群中测试了 ErbB4 与这三种主要精神疾病之间的关联。根据之前的阳性报告和 HapMap 汉族个体（来自北京，CHB）与日本东京个体（JPT）群体的连锁不平衡信息，选择了 5 个单核苷酸多态性（SNP）。这些 SNP 在 1140 名双相情感障碍（BPAD）患者、1140 名精神分裂症（SCZ）患者、1139 名重度抑郁症（MDD）患者和 1140 名正常对照中进行了基因分型。在 BPAD 患者中，有两个 SNP（rs707284 和 rs839523）显示出名义上的显著差异，但在置换后消除了这种差异。未观察到 ErbB4 与另外两种精神疾病之间存在显著关联，单体型分析也未显示任何阳性信号。
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