Feng Yanguo, Cheng Dejun, Zhang Chaofeng, Li Yuchun, Zhang Zhiying, Wang Juan, Feng Xiao
Department of Psychiatry, Henan Mental Hospital, The Second Affiliated Hospital of Xinxiang Medical University, Xinxiang School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Medicine (Baltimore). 2017 Feb;96(8):e5920. doi: 10.1097/MD.0000000000005920.
Accumulating studies have reported inconsistent association between ErbB4 single nucleotide polymorphisms (SNPs) and predisposition to schizophrenia. To better interpret this issue, here we conducted a meta-analysis using published case-control studies.
We conducted a systematic search of MEDLINE (Pubmed), Embase (Ovid), Web of Science (Thomson-Reuters) to identify relevant references. The association between ErbB4 SNPs and schizophrenia was assessed by odds ratios (ORs) and 95% confidence intervals (CIs). Between-study heterogeneity was evaluated by I squared (I) statistics and Cochran's Q test. To appraise the stability of results, we employed sensitivity analysis by omitting 1 single study each time. To assess the potential publication bias, we conducted trim and fill analysis.
Seven studies published in English comprising 3162 cases and 4264 controls were included in this meta-analysis. Meta-analyses showed that rs707284 is statistically significantly associated with schizophrenia susceptibility among Asian and Caucasian populations under the allelic model (OR = 0.91, 95% CI: 0.83-0.99, P = 0.035). Additionally, a marginal association (P < 0.1) was observed between rs707284 and schizophrenia risk among Asian and Caucasian populations under the recessive (OR = 0.85, 95% CI: 0.72-1.01, P = 0.065) and homozygous (OR = 0.84, 95% CI: 0.68-1.03, P = 0.094) models. In the Asian subgroup, rs707284 was also noted to be marginally associated with schizophrenia under the recessive model (OR = 0.84, 95% CI: 0.70-1.00, P = 0.053). However, no statistically significant association was found between rs839523, rs7598440, rs3748962, and rs2371276 and schizophrenia risk.
This meta-analysis suggested that rs707284 may be a potential ErbB4 SNP associated with susceptibility to schizophrenia. Nevertheless, due to the limited sample size in this meta-analysis, more large-scale association studies are still needed to confirm the results.
越来越多的研究报告了表皮生长因子受体4（ErbB4）单核苷酸多态性（SNP）与精神分裂症易感性之间的关联不一致。为了更好地解释这个问题，我们进行了一项荟萃分析，纳入已发表的病例对照研究。
我们系统检索了MEDLINE（PubMed）、Embase（Ovid）、Web of Science（汤森路透）以识别相关参考文献。通过比值比（OR）和95%置信区间（CI）评估ErbB4 SNP与精神分裂症之间的关联。采用I²统计量和Cochrane Q检验评估研究间的异质性。为了评估结果的稳定性，我们每次剔除一项研究进行敏感性分析。为了评估潜在的发表偏倚，我们进行了剪补分析。
本荟萃分析纳入了7项以英文发表的研究，包括3162例病例和4264例对照。荟萃分析表明，在等位基因模型下，rs707284与亚洲和白种人群中精神分裂症易感性具有统计学显著关联（OR = 0.91，95%CI：0.83 - 0.99，P = 0.035）。此外，在隐性（OR = 0.85，95%CI：0.72 - 1.01，P = 0.065）和纯合子（OR = 0.84，95%CI：0.68 - 1.03，P = 0.094）模型下，观察到rs707284与亚洲和白种人群中精神分裂症风险存在边缘关联（P < 0.1）。在亚洲亚组中，在隐性模型下也注意到rs707284与精神分裂症存在边缘关联（OR = 0.84，95%CI：0.70 - 1.00，P = 0.053）。然而，未发现rs839523、rs7598440、rs3748962和rs2371276与精神分裂症风险之间存在统计学显著关联。
本荟萃分析表明，rs707284可能是与精神分裂症易感性相关的潜在ErbB4 SNP。然而，由于本荟萃分析中的样本量有限，仍需要更多大规模的关联研究来证实结果。
