骨髓间充质基质细胞在人类发育和衰老过程中的组成发生变化。
The composition of the mesenchymal stromal cell compartment in human bone marrow changes during development and aging.
机构信息
Department of Experimental Immunohematology, Sanquin Research, Amsterdam, The Netherlands.
出版信息
Haematologica. 2012 Feb;97(2):179-83. doi: 10.3324/haematol.2011.047753. Epub 2011 Oct 11.
Abstract
Life-long hematopoiesis depends on the support of mesenchymal stromal cells within the bone marrow. Therefore, changes in the hematopoietic compartment that occur during development and aging probably correlate with variation in the composition of the stromal cell microenvironment. Mesenchymal stromal cells are a heterogeneous cell population and various subtypes may have different functions. In accordance with others, we show that CD271 and CD146 define distinct colony-forming-unit-fibroblast containing mesenchymal stromal cell subpopulations. In addition, analysis of 86 bone marrow samples revealed that the distribution of CD271(bright)CD146(-) and CD271(bright)CD146(+) subsets correlates with donor age. The main subset in adults was CD271(bright)CD146(-), whereas the CD271(bright)CD146(+) population was dominant in pediatric and fetal bone marrow. A third subpopulation of CD271(-)CD146(+) cells contained colony-forming-unit-fibroblasts in fetal samples only. These changes in composition of the mesenchymal stromal cell compartment during development and aging suggest a dynamic system, in which these subpopulations may have different functions.
摘要
终生造血依赖于骨髓中的间充质基质细胞的支持。因此，在发育和衰老过程中发生的造血区室的变化可能与基质细胞微环境组成的变化相关。间充质基质细胞是一个异质性的细胞群体，各种亚型可能具有不同的功能。与其他人的研究一致，我们表明 CD271 和 CD146 定义了不同的集落形成单位-成纤维细胞，其中包含间充质基质细胞亚群。此外，对 86 份骨髓样本的分析表明，CD271(bright)CD146(-)和 CD271(bright)CD146(+)亚群的分布与供体年龄相关。成人的主要亚群是 CD271(bright)CD146(-)，而 CD271(bright)CD146(+)群体在儿科和胎儿骨髓中占优势。第三个 CD271(-)CD146(+)细胞亚群仅在胎儿样本中包含集落形成单位-成纤维细胞。这些在发育和衰老过程中骨髓间充质基质细胞区室组成的变化表明这是一个动态系统，其中这些亚群可能具有不同的功能。
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