Department of Experimental Medicine, TOR, University of Rome Tor Vergata, Rome, 00133, Italy.
The Third Affiliated Hospital of Soochow University, Institutes for Translational Medicine, State Key Laboratory of Radiation Medicine and Protection, Medical College of Soochow University, Suzhou, Jiangsu, China.
Biol Direct. 2023 Jul 18;18(1):40. doi: 10.1186/s13062-023-00394-6.
Natural ageing of organisms and corresponding age-related diseases result mainly from stem cell ageing and "inflammaging". Mesenchymal stem cells (MSCs) exhibit very high immune-regulating capacity and are promising candidates for immune-related disease treatment. However, the effect of MSC application is not satisfactory for some patients, especially in elderly individuals. With ageing, MSCs undergo many changes, including altered cell population reduction and differentiation ability, reduced migratory and homing capacity and, most important, defective immunosuppression. It is necessary to explore the relationship between the "inflammaging" and aged MSCs to prevent age-related diseases and increase the therapeutic effects of MSCs. In this review, we discuss changes in naturally ageing MSCs mainly from an inflammation perspective and propose some ideas for rejuvenating aged MSCs in future treatments.
生物的自然衰老和相应的与年龄相关的疾病主要源于干细胞衰老和“炎症衰老”。间充质干细胞（MSCs）表现出非常高的免疫调节能力，是治疗与免疫相关疾病的有前途的候选者。然而，对于某些患者，特别是老年人，MSC 的应用效果并不理想。随着年龄的增长，MSCs 发生许多变化，包括细胞群体减少和分化能力改变、迁移和归巢能力降低，最重要的是，免疫抑制功能缺陷。有必要探索“炎症衰老”与衰老 MSCs 之间的关系，以预防与年龄相关的疾病并提高 MSCs 的治疗效果。在这篇综述中，我们主要从炎症角度讨论了自然衰老的 MSCs 的变化，并提出了一些在未来治疗中恢复衰老 MSCs 的想法。
