Department of Neurology, Wakayama Medical University, 840-1 Kimii-dera, Wakayama 641-8510, Japan.
Neurol Sci. 2012 Aug;33(4):765-70. doi: 10.1007/s10072-011-0814-y. Epub 2011 Oct 13.
The nature of the swallowing impairment in patients with sporadic inclusion body myositis (s-IBM) has not been well characterized. In this study, we examined ten consecutive s-IBM patients using videofluoroscopy (VF) and computed pharyngoesophageal manometry (CPM). The patients were divided into two groups: patients with complaint and without complaint of dysphagia. VF results indicated pharyngeal muscle propulsion (PP) at the hypopharyngeal and upper esophagus sphincter (UES) in all s-IBM patients. Patients without complaint of dysphagia showed a mild degree of PP, whereas a severe form of PP was observed in patients with complaint of dysphagia. CPM revealed that negative pressure during UES opening was not observed in the s-IBM patients with complaint of dysphagia. Incomplete opening and PP at the UES were observed in all s-IBM patients. These results indicate that the dysphagic processes occur subclinically in s-IBM patients who may not report swallowing impairments.
散发性包涵体肌炎（s-IBM）患者的吞咽障碍性质尚未得到很好的描述。在这项研究中，我们使用视频透视（VF）和计算机咽食管测压（CPM）检查了 10 例连续 s-IBM 患者。患者分为两组：有吞咽困难主诉和无吞咽困难主诉的患者。VF 结果表明，所有 s-IBM 患者的下咽和食管上括约肌（UES）均有咽肌推进（PP）。无吞咽困难主诉的患者表现为轻度 PP，而有吞咽困难主诉的患者则表现为严重的 PP。CPM 显示，有吞咽困难主诉的 s-IBM 患者UES 开放时未见负压。所有 s-IBM 患者均存在UES 不完全开放和 PP。这些结果表明，s-IBM 患者的吞咽过程可能在临床上无症状，但可能不会报告吞咽障碍。
