Institute of Pathology, University Hospital Bonn, D-53127 Bonn, Germany.
Mol Med Rep. 2012 Jan;5(1):32-6. doi: 10.3892/mmr.2011.628. Epub 2011 Oct 11.
Prostate cancer (PCa) is a clinically heterogeneous and multifocal disease with a clinical outcome that is difficult to predict. Notably, predisposition to develop prostate cancer is different among the prostate zones, with the peripheral zone (PZ) or prostate proper as the most frequent site compared to the transitional zone (TZ). Translocations between the TMPRSS2 gene and a number of members of the ETS family are frequently found in PCa. Here, we examined expression differences among the two zones by laser microdissection of normal tissues from PCa patients to separate glands from stroma, and investigated the gene expression differences in the glands of the PZ compared to those of the TZ using microarray analysis. We identified 9 genes involved in the so-called metastatic cascade, to be highly differentially expressed in the normal glands of the PZ compared to those of the TZ. The genes which were found to be up-regulated in the PZ compared to the TZ are commonly up-regulated in tumors. These findings may explain the lower susceptibility for PCa of the TZ compared to the PZ. According to bioinformatic analysis, 8/9 of these genes may be potentially regulated by ETS transcription factors.
前列腺癌（PCa）是一种临床异质性和多灶性疾病，其临床结果难以预测。值得注意的是，前列腺区域发生前列腺癌的易感性不同，与过渡区（TZ）相比，周围区（PZ）或前列腺固有区是最常见的部位。TMPRSS2 基因与 ETS 家族的许多成员之间的易位在前列腺癌中经常发现。在这里，我们通过对前列腺癌患者的正常组织进行激光显微解剖，将腺体与基质分离，以研究两个区域之间的表达差异，并使用微阵列分析研究 PZ 腺体与 TZ 腺体之间的基因表达差异。我们确定了 9 个参与所谓的转移级联的基因，这些基因在 PZ 的正常腺体中与 TZ 的正常腺体相比高度差异表达。与 TZ 相比，在 PZ 中上调的基因在肿瘤中通常上调。这些发现可以解释 TZ 相对于 PZ 较低的前列腺癌易感性。根据生物信息学分析，这些基因中有 8/9 可能受 ETS 转录因子的潜在调节。
