Department of Neurology, Medical College of Wisconsin, Froedtert Hospital, Milwaukee, Wisconsin, USA.
J Neurointerv Surg. 2009 Jul;1(1):40-3. doi: 10.1136/jnis.2009.000331. Epub 2009 Jul 3.
Two independent post-approval registries have reported favorable periprocedural and short term outcomes with the use of the Wingspan stent for treatment of intracranial arterial stenosis. Data on long term clinical and imaging outcomes after Wingspan stent placement are limited.
All patients treated with the Wingspan stent in a single academic center from January 2006 to February 2008 were identified. Data on stenting indication, severity of stenosis, technical success, re-stenosis and clinical outcome were collected.
51 patients were treated with the Wingspan stent system for a symptomatic intracranial atherosclerotic stenosis of 50-99%. The technical success rate was 98%. The mean pre- and post-stent stenoses were 73 (11)% and 21 (7)%. Any stroke or death within 24 h of the procedure occurred in 1/51 (2%). The frequency of any stroke or death within 30 days or ipsilateral stroke beyond 30 days was 5/51 (10.0%) at a mean follow-up time of 14.6 months (range 8-30). The frequency of ≥ 50% re-stenosis on follow-up imaging was 7/29 (24%) at 8.6 (4.4) months (range 3-20); all were detected on the initial imaging within 3-6 months, and only one was symptomatic.
The use of the Wingspan stent in patients with ≥50% symptomatic intracranial stenosis is associated with good long term clinical outcome. One stroke occurred after the first 30 days, suggesting a significant stabilization of the adverse event rate after the first month.
两项独立的上市后注册研究报告了使用 Wingspan 支架治疗颅内动脉狭窄的围手术期和短期结果良好。关于 Wingspan 支架置入后的长期临床和影像学结果的数据有限。
在单一学术中心，从 2006 年 1 月至 2008 年 2 月，确定了所有接受 Wingspan 支架治疗的患者。收集了支架置入指征、狭窄严重程度、技术成功率、再狭窄和临床结果的数据。
51 例患者因症状性颅内动脉粥样硬化狭窄 50-99%而行 Wingspan 支架治疗。技术成功率为 98%。支架置入前和支架置入后的狭窄程度分别为 73%（11）和 21%（7）。51 例患者中有 1 例（2%）在术后 24 小时内发生任何卒中或死亡。30 天内任何卒中或死亡或 30 天后同侧卒中的发生率为 5/51（10.0%），平均随访时间为 14.6 个月（范围 8-30）。在 8.6（4.4）个月（范围 3-20）的随访影像学上，≥50%再狭窄的发生率为 7/29（24%）；所有患者在最初的 3-6 个月的影像学检查中都被发现，只有 1 例有症状。
在≥50%症状性颅内狭窄的患者中使用 Wingspan 支架与良好的长期临床结果相关。1 例患者在第一个 30 天后发生卒中，提示在第一个月后不良事件发生率显著稳定。
