Laboratory of Clinical Pharmacology, Rigshospitalet, Copenhagen, Denmark.
Diabetes Care. 2011 Dec;34(12):2594-6. doi: 10.2337/dc11-1620. Epub 2011 Oct 12.
We analyzed data from a cohort of 1,381 newly diagnosed type 2 diabetic patients to test the hypothesis that urinary markers of nucleic acid oxidation are independent predictors of mortality.
We examined the relationship between urinary excretion of markers of DNA oxidation (8-oxo-7,8-dihydro-2'-deoxyguanosine [8-oxodG]) and RNA oxidation (8-oxo-7,8-dihydroguanosine [8-oxoGuo]) and long-term mortality using Cox proportional hazards regression.
After multivariate adjustment, the hazard ratios for all-cause and diabetes-related mortality of patients with 8-oxoGuo levels in the highest quartile compared with those in the lowest quartile were 1.44 (1.12-1.85) and 1.54 (1.13-2.10), respectively. Conversely, no significant associations between 8-oxodG and mortality were found in the adjusted analyses.
Urinary excretion of the RNA oxidation marker 8-oxoGuo measured shortly after diagnosis of type 2 diabetes predicts long-term mortality independently of conventional risk factors. This finding suggests that 8-oxoGuo could serve as a new clinical biomarker in diabetes.
我们分析了 1381 例新诊断 2 型糖尿病患者的队列数据，以检验尿中核酸氧化标志物是否可独立预测死亡率这一假说。
我们采用 Cox 比例风险回归分析，研究了 DNA 氧化（8-氧代-7,8-二氢-2′-脱氧鸟苷[8-oxodG]）和 RNA 氧化（8-氧代-7,8-二氢鸟苷[8-oxoGuo]）标志物的尿排泄与长期死亡率之间的关系。
经多变量校正后，8-oxoGuo 水平最高四分位数患者的全因死亡率和糖尿病相关死亡率的危险比（HR）分别为 1.44（1.12-1.85）和 1.54（1.13-2.10）。相比之下，校正分析中 8-oxodG 与死亡率之间无显著相关性。
2 型糖尿病诊断后不久即检测到的尿 RNA 氧化标志物 8-oxoGuo 可独立于传统危险因素预测长期死亡率。这一发现提示 8-oxoGuo 可作为糖尿病的一种新的临床生物标志物。
