Calcutt Nigel A, Cooper Mark E, Kern Tim S, Schmidt Ann Marie
Department of Pathology, University of California, San Diego, La Jolla, California 92093, USA.
Nat Rev Drug Discov. 2009 May;8(5):417-29. doi: 10.1038/nrd2476.
Long-term diabetes increases the likelihood of developing secondary damage to numerous systems, and these complications represent a substantial cause of morbidity and mortality. Establishing the causes of diabetes remains the key step towards eradicating the disease, but the prevention and amelioration of diabetic complications is equally important for the millions of individuals who already have the disease or are likely to develop it before prophylaxis or a cure become routinely available. In this Review, we focus on four common complications of diabetes, discuss the range of pathologies that are precipitated by hyperglycaemia and highlight emerging targets for therapeutic intervention.
长期糖尿病会增加许多系统发生继发性损害的可能性，而这些并发症是发病和死亡的重要原因。确定糖尿病的病因仍然是根除该疾病的关键步骤，但对于数百万已经患有糖尿病或在预防或治愈方法常规可用之前可能会患上糖尿病的人来说，预防和改善糖尿病并发症同样重要。在本综述中，我们重点关注糖尿病的四种常见并发症，讨论高血糖引发的一系列病理状况，并强调新兴的治疗干预靶点。
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