Department of Medicine II, University Hospital Freiburg, 79106 Freiburg, Germany.
Viruses. 2009 Sep;1(2):104-125. doi: 10.3390/v1020104. Epub 2009 Aug 5.
The natural history of hepatitis C virus (HCV) infection is determined by a complex interplay between host genetic, immunological and viral factors. This review highlights genes involved in innate and adaptive immune responses associated with different outcomes of HCV infection. For example, an association of HCV clearance with certain HLA alleles has been demonstrated. The mechanisms responsible for these associations have been linked to specific T cell responses for some particular alleles (e.g., HLA-B27). Genetic associations involved in T cell regulation and function further underline the role of the adaptive immune response in the natural history of HCV infection. In addition, some genes involved in innate NK cell responses demonstrate the complex interplay between components of the immune system necessary for a successful host response to HCV infection.
丙型肝炎病毒 (HCV) 感染的自然史是由宿主遗传、免疫和病毒因素之间的复杂相互作用决定的。这篇综述强调了与 HCV 感染不同结局相关的固有和适应性免疫反应中涉及的基因。例如，已经证明了 HCV 清除与某些 HLA 等位基因有关。这些关联的机制与某些特定等位基因（例如 HLA-B27）的特定 T 细胞反应有关。参与 T 细胞调节和功能的遗传关联进一步强调了适应性免疫反应在 HCV 感染自然史中的作用。此外，一些涉及固有 NK 细胞反应的基因表明，固有免疫反应和 NK 细胞反应的相互作用是宿主对 HCV 感染成功反应所必需的。
