Institut Pasteur du Cambodge, Virology Unit, 5 Monivong boulevard, PO Box 983, Phnom Penh, Cambodia; E-Mails:
Viruses. 2009 Dec;1(3):335-61. doi: 10.3390/v1030335. Epub 2009 Oct 6.
Highly Pathogenic Avian Influenza (HPAI) H5N1 virus is an ongoing public health and socio-economic challenge, particularly in South East Asia. H5N1 is now endemic in poultry in many countries, and represents a major pandemic threat. Here, we describe the evolution of H5N1 virus in South East Asia, the reassortment events leading to high genetic diversity in the region, and factors responsible for virus spread. The virus has evolved with genetic variations affecting virulence, drug-resistance, and adaptation to new host species. The constant surveillance of these changes is of primary importance in the global efforts of the scientific community.
高致病性禽流感（HPAI）H5N1 病毒是一个持续存在的公共卫生和社会经济挑战，特别是在东南亚地区。H5N1 现在在许多国家的家禽中流行，是一个主要的大流行威胁。在这里，我们描述了东南亚地区 H5N1 病毒的演变，导致该地区高度遗传多样性的重配事件，以及病毒传播的因素。该病毒发生了遗传变异，影响了毒力、耐药性和对新宿主物种的适应性。在科学界的全球努力中，对这些变化的持续监测至关重要。
