Université de la Méditerranée, Centre d'Immunologie de Marseille-Luminy, Parc Scientifique & Technologique de Luminy, Case 906, F13288 Marseille, Cedex 09, France; E-Mails:
Viruses. 2009 Dec;1(3):383-419. doi: 10.3390/v1030383. Epub 2009 Oct 14.
Type-I interferons (IFN-I) are cytokines essential for vertebrate antiviral defense, including against herpesviruses. IFN-I have potent direct antiviral activities and also mediate a multiplicity of immunoregulatory functions, which can either promote or dampen antiviral adaptive immune responses. Plasmacytoid dendritic cells (pDCs) are the professional producers of IFN-I in response to many viruses, including all of the herpesviruses tested. There is strong evidence that pDCs could play a major role in the initial orchestration of both innate and adaptive antiviral immune responses. Depending on their activation pattern, pDC responses may be either protective or detrimental to the host. Here, we summarize and discuss current knowledge regarding pDC implication in the physiopathology of mouse and human herpesvirus infections, and we discuss how pDC functions could be manipulated in immunotherapeutic settings to promote health over disease.
I 型干扰素 (IFN-I) 是脊椎动物抗病毒防御的必需细胞因子，包括对抗疱疹病毒。IFN-I 具有强大的直接抗病毒活性，还介导多种免疫调节功能，这些功能既可以促进也可以抑制抗病毒适应性免疫反应。浆细胞样树突状细胞 (pDC) 是对多种病毒（包括所有测试的疱疹病毒）产生 IFN-I 的专业细胞。有强有力的证据表明，pDC 可能在先天和适应性抗病毒免疫反应的初始协调中发挥主要作用。根据其激活模式，pDC 反应可能对宿主有益或有害。在这里，我们总结并讨论了当前关于 pDC 在小鼠和人类疱疹病毒感染的病理生理学中的作用的知识，并讨论了如何在免疫治疗环境中操纵 pDC 功能，以促进健康而非疾病。
