Myrdalskogen 95, N-5117 Ulset, Norway.
Viruses. 2009 Dec;1(3):1089-109. doi: 10.3390/v1031089. Epub 2009 Dec 3.
Recent years' enzootic spread of highly pathogenic H5N1 virus among poultry and the many lethal zoonoses in its wake has stimulated basic and applied pandemic vaccine research. The quest for an efficacious, affordable and timely accessible pandemic vaccine has been high on the agenda. When a variant H1N1 strain of swine origin emerged as a pandemic virus, it surprised many, as this subtype is well-known to man as a seasonal virus. This review will cover some difficult vaccine questions, such as the immunological challenges, the new production platforms, and the limited supply and global equity issues.
近年来，高致病性 H5N1 病毒在家禽中的地方性流行以及随之而来的许多致死性人畜共患病刺激了基础和应用大流行疫苗研究。寻求一种有效、经济实惠且及时可及的大流行疫苗一直是重中之重。当一种源自猪的新型 H1N1 变异株成为大流行病毒时，许多人感到惊讶，因为这种亚型是人所熟知的季节性病毒。本综述将涵盖一些困难的疫苗问题，例如免疫挑战、新的生产平台以及有限的供应和全球公平问题。
