大流行性流感疫苗——面临的挑战。
Pandemic influenza vaccines - the challenges.
机构信息
Myrdalskogen 95, N-5117 Ulset, Norway.
出版信息
Viruses. 2009 Dec;1(3):1089-109. doi: 10.3390/v1031089. Epub 2009 Dec 3.
Abstract
Recent years' enzootic spread of highly pathogenic H5N1 virus among poultry and the many lethal zoonoses in its wake has stimulated basic and applied pandemic vaccine research. The quest for an efficacious, affordable and timely accessible pandemic vaccine has been high on the agenda. When a variant H1N1 strain of swine origin emerged as a pandemic virus, it surprised many, as this subtype is well-known to man as a seasonal virus. This review will cover some difficult vaccine questions, such as the immunological challenges, the new production platforms, and the limited supply and global equity issues.
摘要
近年来，高致病性 H5N1 病毒在家禽中的地方性流行以及随之而来的许多致死性人畜共患病刺激了基础和应用大流行疫苗研究。寻求一种有效、经济实惠且及时可及的大流行疫苗一直是重中之重。当一种源自猪的新型 H1N1 变异株成为大流行病毒时，许多人感到惊讶，因为这种亚型是人所熟知的季节性病毒。本综述将涵盖一些困难的疫苗问题，例如免疫挑战、新的生产平台以及有限的供应和全球公平问题。
相似文献
1
Pandemic influenza vaccines - the challenges.
Viruses. 2009 Dec;1(3):1089-109. doi: 10.3390/v1031089. Epub 2009 Dec 3.
2
Vaccination with Recombinant Parainfluenza Virus 5 Expressing Neuraminidase Protects against Homologous and Heterologous Influenza Virus Challenge.
J Virol. 2017 Nov 14;91(23). doi: 10.1128/JVI.01579-17. Print 2017 Dec 1.
3
Universal Influenza Virus Neuraminidase Vaccine Elicits Protective Immune Responses against Human Seasonal and Pre-pandemic Strains.
J Virol. 2021 Aug 10;95(17):e0075921. doi: 10.1128/JVI.00759-21.
4
M2SR, a novel live influenza vaccine, protects mice and ferrets against highly pathogenic avian influenza.
Vaccine. 2017 Jul 24;35(33):4177-4183. doi: 10.1016/j.vaccine.2017.06.039. Epub 2017 Jun 28.
5
The 2009 pandemic H1N1 virus induces anti-neuraminidase (NA) antibodies that cross-react with the NA of H5N1 viruses in ferrets.
Vaccine. 2012 Mar 28;30(15):2516-22. doi: 10.1016/j.vaccine.2012.01.090. Epub 2012 Feb 11.
6
Multi-Influenza HA Subtype Protection of Ferrets Vaccinated with an N1 COBRA-Based Neuraminidase.
Viruses. 2023 Jan 9;15(1):184. doi: 10.3390/v15010184.
7
A VLP vaccine induces broad-spectrum cross-protective antibody immunity against H5N1 and H1N1 subtypes of influenza A virus.
PLoS One. 2012;7(8):e42363. doi: 10.1371/journal.pone.0042363. Epub 2012 Aug 7.
8
Epidemiology, ecology and gene pool of influenza A virus in Egypt: will Egypt be the epicentre of the next influenza pandemic?
Virulence. 2015;6(1):6-18. doi: 10.4161/21505594.2014.992662.
9
An H5N1 M2e-based multiple antigenic peptide vaccine confers heterosubtypic protection from lethal infection with pandemic 2009 H1N1 virus.
Virol J. 2010 Jul 12;7:151. doi: 10.1186/1743-422X-7-151.
10
Detection and Characterization of Swine Origin Influenza A(H1N1) Pandemic 2009 Viruses in Humans following Zoonotic Transmission.
J Virol. 2020 Dec 22;95(2). doi: 10.1128/JVI.01066-20.
引用本文的文献
1
Microarray Gene Expression Dataset Re-analysis Reveals Variability in Influenza Infection and Vaccination.
Front Immunol. 2019 Nov 7;10:2616. doi: 10.3389/fimmu.2019.02616. eCollection 2019.
2
A systematic review and meta-analysis of cross-reactivity of antibodies induced by H7 influenza vaccine.
Hum Vaccin Immunother. 2020;16(2):286-294. doi: 10.1080/21645515.2019.1649551. Epub 2019 Aug 23.
3
Comparative effectiveness of H7N9 vaccines in healthy individuals.
Hum Vaccin Immunother. 2019;15(1):80-90. doi: 10.1080/21645515.2018.1515454. Epub 2018 Sep 14.
4
Controlling epidemics with transmissible vaccines.
PLoS One. 2018 May 10;13(5):e0196978. doi: 10.1371/journal.pone.0196978. eCollection 2018.
5
Oral immunization of a non-recombinant Lactococcus lactis surface displaying influenza hemagglutinin 1 (HA1) induces mucosal immunity in mice.
PLoS One. 2017 Nov 6;12(11):e0187718. doi: 10.1371/journal.pone.0187718. eCollection 2017.
6
Equalizing access to pandemic influenza vaccines through optimal allocation to public health distribution points.
PLoS One. 2017 Aug 30;12(8):e0182720. doi: 10.1371/journal.pone.0182720. eCollection 2017.
7
Available influenza vaccines: immunization strategies, history and new tools for fighting the disease.
J Prev Med Hyg. 2016;57(1):E41-6.
8
Pretreatment of mice with oligonucleotide prop5 protects them from influenza virus infections.
Viruses. 2014 Feb 6;6(2):573-81. doi: 10.3390/v6020573.
9
Influenza Virus-like Particle Containing Two Different Subtypes of Hemagglutinin Confers Protection in Mice Against Lethal Challenge With A/PR8 (H1N1) and A/HK (H3N2) Viruses.
Iran Red Crescent Med J. 2013 Jan;15(1):75-82. doi: 10.5812/ircmj.6252. Epub 2013 Jan 5.
10
Advances and future challenges in recombinant adenoviral vectored H5N1 influenza vaccines.
Viruses. 2012 Nov 1;4(11):2711-35. doi: 10.3390/v4112711.
本文引用的文献
1
Pre-existing immunity against swine-origin H1N1 influenza viruses in the general human population.
Proc Natl Acad Sci U S A. 2009 Dec 1;106(48):20365-70. doi: 10.1073/pnas.0911580106. Epub 2009 Nov 16.
2
Effectiveness of 2008-09 trivalent influenza vaccine against 2009 pandemic influenza A (H1N1) - United States, May-June 2009.
MMWR Morb Mortal Wkly Rep. 2009 Nov 13;58(44):1241-5.
3
A novel influenza A (H1N1) vaccine in various age groups.
N Engl J Med. 2009 Dec 17;361(25):2414-23. doi: 10.1056/NEJMoa0908535. Epub 2009 Oct 21.
4
Partial protection of seasonal trivalent inactivated vaccine against novel pandemic influenza A/H1N1 2009: case-control study in Mexico City.
BMJ. 2009 Oct 6;339:b3928. doi: 10.1136/bmj.b3928.
5
Intramuscular Matrix-M-adjuvanted virosomal H5N1 vaccine induces high frequencies of multifunctional Th1 CD4+ cells and strong antibody responses in mice.
Vaccine. 2009 Dec 9;27(52):7367-76. doi: 10.1016/j.vaccine.2009.09.044. Epub 2009 Sep 23.
6
Response to a monovalent 2009 influenza A (H1N1) vaccine.
N Engl J Med. 2009 Dec 17;361(25):2405-13. doi: 10.1056/NEJMoa0907413. Epub 2009 Sep 10.
7
Trial of 2009 influenza A (H1N1) monovalent MF59-adjuvanted vaccine.
N Engl J Med. 2009 Dec 17;361(25):2424-35. doi: 10.1056/NEJMoa0907650. Epub 2009 Sep 10.
8
Cross-reactive antibody responses to the 2009 pandemic H1N1 influenza virus.
N Engl J Med. 2009 Nov 12;361(20):1945-52. doi: 10.1056/NEJMoa0906453. Epub 2009 Sep 10.
9
Dating the emergence of pandemic influenza viruses.
Proc Natl Acad Sci U S A. 2009 Jul 14;106(28):11709-12. doi: 10.1073/pnas.0904991106. Epub 2009 Jul 13.
10
Historical perspective--Emergence of influenza A (H1N1) viruses.
N Engl J Med. 2009 Jul 16;361(3):279-85. doi: 10.1056/NEJMra0904322. Epub 2009 Jun 29.
Zotero 插件