Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, T6G 2S2, Canada.
Viruses. 2010 Oct;2(10):2356-2380. doi: 10.3390/v2102356. Epub 2010 Oct 19.
Ubiquitination plays a critical role in many cellular processes. A growing number of viruses have evolved strategies to exploit the ubiquitin-proteasome system, including members of the Poxviridae family. Members of the poxvirus family have recently been shown to encode BTB/kelch and ankyrin/F-box proteins that interact with cullin-3 and cullin-1 based ubiquitin ligases, respectively. Multiple members of the poxvirus family also encode ubiquitin ligases with intrinsic activity. This review describes the numerous mechanisms that poxviruses employ to manipulate the ubiquitin-proteasome system.
泛素化在许多细胞过程中起着关键作用。越来越多的病毒已经进化出利用泛素-蛋白酶体系统的策略，包括痘病毒家族的成员。最近已经表明，痘病毒家族的成员编码 BTB/kelch 和锚蛋白/F-box 蛋白，它们分别与基于 cullin-3 和 cullin-1 的泛素连接酶相互作用。痘病毒家族的多个成员还编码具有内在活性的泛素连接酶。本文综述了痘病毒用来操纵泛素-蛋白酶体系统的多种机制。
