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RNA 复制子——流感病毒免疫预防的新方法。

RNA replicons - a new approach for influenza virus immunoprophylaxis.

机构信息

Institute of Virology and Immunoprophylaxis (IVI), Sensemattstrasse 293, CH-3147 Mittelhäusern, Switzerland.

出版信息

Viruses. 2010 Feb;2(2):413-434. doi: 10.3390/v2020413. Epub 2010 Jan 29.

DOI:10.3390/v2020413
PMID:21994644
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3185613/
Abstract

RNA replicons are derived from either positive- or negative-strand RNA viruses. They represent disabled virus vectors that are not only avirulent, but also unable to revert to virulence. Due to autonomous RNA replication, RNA replicons are able to drive high level, cytosolic expression of recombinant antigens stimulating both the humoral and the cellular branch of the immune system. This review provides an update on the available literature covering influenza virus vaccines based on RNA replicons. The pros and cons of these vaccine strategies will be discussed and future perspectives disclosed.

摘要

RNA 复制子来源于正链或负链 RNA 病毒。它们代表了无毒性的病毒载体，不仅没有毒力，而且也无法恢复毒力。由于自主 RNA 复制，RNA 复制子能够在细胞质中高水平表达重组抗原，刺激体液和细胞免疫的分支。本文综述了基于 RNA 复制子的流感病毒疫苗的现有文献，介绍了该领域的最新进展。讨论了这些疫苗策略的优缺点，并揭示了未来的研究方向。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5479/3185613/dd08e6d6d80d/viruses-02-00413f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5479/3185613/093c5af6f1a2/viruses-02-00413f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5479/3185613/dd08e6d6d80d/viruses-02-00413f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5479/3185613/093c5af6f1a2/viruses-02-00413f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5479/3185613/dd08e6d6d80d/viruses-02-00413f2.jpg

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Evaluation of two live attenuated cold-adapted H5N1 influenza virus vaccines in healthy adults.两种减毒活冷适应H5N1流感病毒疫苗在健康成年人中的评估。
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mRNA vaccine for cancer immunotherapy.用于癌症免疫治疗的信使核糖核酸疫苗
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Semliki Forest Virus replicon particles production in serum-free medium BHK-21 cell cultures and their use to express different proteins.在无血清培养基的BHK - 21细胞培养物中生产Semliki森林病毒复制子颗粒及其用于表达不同蛋白质的用途。
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