细胞脂质在正链 RNA 病毒复制复合物组装和功能中的作用。
Role of cellular lipids in positive-sense RNA virus replication complex assembly and function.
机构信息
Section of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06519, USA.
Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
出版信息
Viruses. 2010 May;2(5):1055-1068. doi: 10.3390/v2051055. Epub 2010 Apr 29.
Positive-sense RNA viruses are responsible for frequent and often devastating diseases in humans, animals, and plants. However, the development of effective vaccines and anti-viral therapies targeted towards these pathogens has been hindered by an incomplete understanding of the molecular mechanisms involved in viral replication. One common feature of all positive-sense RNA viruses is the manipulation of host intracellular membranes for the assembly of functional viral RNA replication complexes. This review will discuss the interplay between cellular membranes and positive-sense RNA virus replication, and will focus specifically on the potential structural and functional roles for cellular lipids in this process.
正链 RNA 病毒可引起人类、动物和植物中频繁且往往是破坏性极大的疾病。然而，由于对病毒复制过程中涉及的分子机制了解不完整，针对这些病原体的有效疫苗和抗病毒疗法的发展受到了阻碍。所有正链 RNA 病毒的一个共同特征是操纵宿主细胞内的膜，用于组装功能性病毒 RNA 复制复合物。本综述将讨论细胞内膜与正链 RNA 病毒复制之间的相互作用，并特别关注细胞脂质在这一过程中的潜在结构和功能作用。
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