Aliyari Saba R, Quanquin Natalie, Pernet Olivier, Zhang Shilei, Wang Lulan, Cheng Genhong
Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, CA 90095, USA.
Department of Pediatrics, Division of Infectious Diseases, Children's Hospital Los Angeles, Los Angeles, CA 90027, USA.
Pathogens. 2022 May 3;11(5):538. doi: 10.3390/pathogens11050538.
Compared to what we knew at the start of the SARS-CoV-2 global pandemic, our understanding of the interplay between the interferon signaling pathway and SARS-CoV-2 infection has dramatically increased. Innate antiviral strategies range from the direct inhibition of viral components to reprograming the host's own metabolic pathways to block viral infection. SARS-CoV-2 has also evolved to exploit diverse tactics to overcome immune barriers and successfully infect host cells. Herein, we review the current knowledge of the innate immune signaling pathways triggered by SARS-CoV-2 with a focus on the type I interferon response, as well as the mechanisms by which SARS-CoV-2 impairs those defenses.
与我们在新冠病毒全球大流行开始时所了解的情况相比，我们对干扰素信号通路与新冠病毒感染之间相互作用的理解有了显著增加。先天性抗病毒策略包括直接抑制病毒成分，到重新编程宿主自身的代谢途径以阻断病毒感染。新冠病毒也进化出了多种策略来克服免疫障碍并成功感染宿主细胞。在此，我们综述了目前关于新冠病毒引发的先天性免疫信号通路的知识，重点是I型干扰素反应，以及新冠病毒损害这些防御机制的方式。
