Immunology and Molecular Oncology Unit, Veneto Institute of Oncology IOV-IRCCS, via Gattamelata 64, 35128 Padova, Italy.
Viruses. 2011 Jul;3(7):1001-14. doi: 10.3390/v3071001. Epub 2011 Jun 27.
The NF-κB pathway is intimately linked to the survival of mammalian cells, and its activation by Tax has consequently been considered important for human T-cell leukemia/lymphoma virus type 1 (HTLV-1)-infected cell resistance to death. Very little emphasis has been given to other mechanisms, although Tax regulates the expression and activity of several cellular genes. The finding that CREB protein is activated in HTLV-1 infected cells underlines the possibility that other mechanisms of survival may be implicated in HTLV-1 infection. Indeed, CREB activation or overexpression plays a role in normal hematopoiesis, as well as in leukemia development, and CREB is considered as a survival factor in various cell systems. A better understanding of the different molecular mechanisms used by Tax to counteract cell death will also help in the development of new therapeutic strategies for HTLV-1 associated diseases.
NF-κB 途径与哺乳动物细胞的存活密切相关，其被 Tax 激活，因此被认为对人类 T 细胞白血病/淋巴瘤病毒 1（HTLV-1）感染细胞抵抗死亡很重要。尽管 Tax 调节几种细胞基因的表达和活性，但很少强调其他机制。发现在 HTLV-1 感染的细胞中 CREB 蛋白被激活，这强调了其他存活机制可能与 HTLV-1 感染有关。事实上，CREB 的激活或过表达在正常造血以及白血病的发展中起作用，并且 CREB 被认为是各种细胞系统中的存活因子。更好地了解 Tax 用来对抗细胞死亡的不同分子机制，也将有助于开发针对 HTLV-1 相关疾病的新的治疗策略。
