转录因子 CREB 在免疫功能中的作用。
The role of the transcription factor CREB in immune function.
机构信息
Division of Pediatric Critical Care, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA.
出版信息
J Immunol. 2010 Dec 1;185(11):6413-9. doi: 10.4049/jimmunol.1001829.
Abstract
CREB is a transcription factor that regulates diverse cellular responses, including proliferation, survival, and differentiation. CREB is induced by a variety of growth factors and inflammatory signals and subsequently mediates the transcription of genes containing a cAMP-responsive element. Several immune-related genes possess this cAMP-responsive element, including IL-2, IL-6, IL-10, and TNF-α. In addition, phosphorylated CREB has been proposed to directly inhibit NF-κB activation by blocking the binding of CREB binding protein to the NF-κB complex, thereby limiting proinflammatory responses. CREB also induces an antiapoptotic survival signal in monocytes and macrophages. In T and B cells, CREB activation promotes proliferation and survival and differentially regulates Th1, Th2, and Th17 responses. Finally, CREB activation is required for the generation and maintenance of regulatory T cells. This review summarizes current advances involving CREB in immune function--a role that is continually being defined.
摘要
CREB 是一种转录因子，可调节多种细胞反应，包括增殖、存活和分化。CREB 可被多种生长因子和炎症信号诱导，随后介导含有 cAMP 反应元件的基因的转录。一些与免疫相关的基因具有此 cAMP 反应元件，包括 IL-2、IL-6、IL-10 和 TNF-α。此外，磷酸化 CREB 已被提出通过阻止 CREB 结合蛋白与 NF-κB 复合物的结合来直接抑制 NF-κB 激活，从而限制促炎反应。CREB 还在单核细胞和巨噬细胞中诱导抗凋亡存活信号。在 T 和 B 细胞中，CREB 激活促进增殖和存活，并差异调节 Th1、Th2 和 Th17 反应。最后，CREB 激活是生成和维持调节性 T 细胞所必需的。这篇综述总结了 CREB 在免疫功能中的最新进展——这一作用仍在不断被定义。
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