Sanford-Burnham Medical Research Institute at Lake Nona, 6400 Sanger Road, Orlando, Florida 32827, USA.
Nat Rev Mol Cell Biol. 2011 Mar;12(3):141-51. doi: 10.1038/nrm3072.
The cyclic AMP-responsive element-binding protein (CREB) is phosphorylated in response to a wide variety of signals, yet target gene transcription is only increased in a subset of cases. Recent studies indicate that CREB functions in concert with a family of latent cytoplasmic co-activators called cAMP-regulated transcriptional co-activators (CRTCs), which are activated through dephosphorylation. A dual requirement for CREB phosphorylation and CRTC dephosphorylation is likely to explain how these activator-co-activator cognates discriminate between different stimuli. Following their activation, CREB and CRTCs mediate the effects of fasting and feeding signals on the expression of metabolic programmes in insulin-sensitive tissues.
环腺苷酸反应元件结合蛋白（CREB）在响应各种信号时会发生磷酸化，但其靶基因转录仅在某些情况下增加。最近的研究表明，CREB 与一组称为 cAMP 调节转录共激活因子（CRTCs）的潜在细胞质共激活因子协同作用，后者通过去磷酸化而被激活。CREB 磷酸化和 CRTC 去磷酸化的双重需求可能解释了这些激活剂-共激活剂同源物如何区分不同的刺激。在激活后，CREB 和 CRTC 介导禁食和进食信号对胰岛素敏感组织中代谢程序表达的影响。
