Madan Kaushal, Mehta Ashish
Medanta Institute of Digestive and Hepatobiliary Sciences, Medanta-The Medicity Hospital, Sector 38, Gurgaon, Haryana 122001, India.
Int J Hepatol. 2011;2011:790232. doi: 10.4061/2011/790232. Epub 2011 Sep 27.
Ascites and renal dysfunction in cirrhosis occur when the liver disease is decompensated and signify the presence of advanced liver failure. However, the precipitating causes should be looked for and treated. Although liver transplantation is the treatment of choice in patients with advanced liver failure, mild to moderate ascites can be treated effectively with medical management. Similarly, renal failure in cirrhotics is reversible if the precipitating causes can be treated effectively and by use of combination of vasoconstrictors and albumin. Transjugular intrahepatic portosystemic shunts also offer an effective therapy for refractory ascites and HRS. Such treatments may offer effective bridge to liver transplantation, by improving short and medium term survivals. Here, we shall discuss all the options available for the management of these complications of cirrhosis.
肝硬化患者出现腹水和肾功能不全表明肝脏疾病已失代偿,意味着存在晚期肝衰竭。然而,应寻找并治疗其诱发原因。虽然肝移植是晚期肝衰竭患者的首选治疗方法,但轻度至中度腹水可通过药物治疗有效控制。同样,如果能有效治疗诱发原因并联合使用血管收缩剂和白蛋白,肝硬化患者的肾衰竭是可逆的。经颈静脉肝内门体分流术也为难治性腹水和肝肾综合征提供了一种有效治疗方法。通过提高短期和中期生存率,此类治疗可为肝移植提供有效的过渡。在此,我们将讨论肝硬化这些并发症的所有可用治疗方案。