Fava G, Lorenzini I
Division of Gastroenterology, Azienda Ospedaliero-Universitaria "Ospedali Riuniti" Via Conca 72, 60020 Ancona, Italy.
Int J Hepatol. 2012;2012:630543. doi: 10.1155/2012/630543. Epub 2011 Jul 21.
Epidemiological data from the last years show an increasing trend of incidence and mortality of cholangiocarcinoma (CC) worldwide. Many pathophysiologic aspects of this neoplasia are still unknown and need to be fully discovered. However, several progresses were recently made in order to establish the molecular mechanisms involved in the transformation and growth of malignant cholangiocytes. The principal concept that at least seems to be established is that cholangiocarcinogenesis is a multistep cellular process evolving from a normal condition of the epithelial biliary cells through a chronic inflammation status ending with malignant transformation. The bad prognosis related to CC justifies why a better identification of the molecular mechanisms involved in the growth and progression of this cancer is required for the development of effective preventive measures and valid treatment regimens. This Paper describes the scientific progresses made in the last years in defining the molecular pathways implicated in the generation of this devastating disease.
过去几年的流行病学数据显示，全球范围内胆管癌（CC）的发病率和死亡率呈上升趋势。这种肿瘤的许多病理生理方面仍然未知，需要全面探索。然而，最近在确定参与恶性胆管细胞转化和生长的分子机制方面取得了一些进展。至少似乎已经确立的主要概念是，胆管癌发生是一个多步骤的细胞过程，从上皮胆管细胞的正常状态通过慢性炎症状态演变至恶性转化。与胆管癌相关的不良预后证明，为了制定有效的预防措施和有效的治疗方案，需要更好地识别参与这种癌症生长和进展的分子机制。本文描述了近年来在确定与这种毁灭性疾病发生相关的分子途径方面取得的科学进展。
