Harada Kenichi, Nakanuma Yasuni
Department of Human Pathology, Kanazawa University Graduate School of Medical Science, Kanazawa 920-8640, Japan.
Int J Hepatol. 2012;2012:793569. doi: 10.1155/2012/793569. Epub 2011 Aug 11.
Biliary innate immunity is involved in the pathogenesis of cholangiopathies in cases of biliary disease. Cholangiocytes possess Toll-like receptors (TLRs) which recognize pathogen-associated molecular patterns (PAMPs) and play a pivotal role in the innate immune response. Tolerance to bacterial PAMPs such as lipopolysaccharides is also important to maintain homeostasis in the biliary tree, but tolerance to double-stranded RNA (dsRNA) is not found. Moreover, in primary biliary cirrhosis (PBC) and biliary atresia, biliary innate immunity is closely associated with the dysregulation of the periductal cytokine milieu and the induction of biliary apoptosis and epithelial-mesenchymal transition (EMT), forming in disease-specific cholangiopathy. Biliary innate immunity is associated with the pathogenesis of various cholangiopathies in biliary diseases as well as biliary defense systems.
在胆汁疾病中,胆道固有免疫参与胆管病的发病机制。胆管细胞拥有Toll样受体(TLRs),其可识别病原体相关分子模式(PAMPs),并在固有免疫反应中起关键作用。对诸如脂多糖等细菌PAMPs的耐受性对于维持胆管树的内环境稳定也很重要,但未发现对双链RNA(dsRNA)的耐受性。此外,在原发性胆汁性肝硬化(PBC)和胆道闭锁中,胆道固有免疫与导管周围细胞因子环境失调以及胆管细胞凋亡和上皮-间质转化(EMT)的诱导密切相关,从而形成疾病特异性胆管病。胆道固有免疫与胆汁疾病中各种胆管病的发病机制以及胆道防御系统相关。