Koda Stephane, Zhu Xing-Quan, Zheng Kui-Yang, Yan Chao
Jiangsu Key Laboratory of Immunity and Metabolism, Xuzhou Laboratory of Infection and Immunity, Department of Pathogenic Biology and Immunology, National Experimental Demonstration Center for Basic Medicine Education, Xuzhou Medical University, Xuzhou, China.
College of Veterinary Medicine, Shanxi Agricultural University, Taigu, China.
Front Cell Dev Biol. 2022 Jan 18;9:781768. doi: 10.3389/fcell.2021.781768. eCollection 2021.
Infections caused by remain a significant public health challenge for both humans and animals, causing pyogenic cholangitis, cholelithiasis, cholecystitis, biliary fibrosis, and even cholangiocarcinoma. However, the strategies used by the parasite and the immunological mechanisms used by the host have not yet been fully understood. With the advances in technologies and the accumulated knowledge of host-parasite interactions, many vaccine candidates against liver flukes have been investigated using different strategies. In this review, we explore and analyze in-depth the immunological mechanisms involved in the pathogenicity of . We highlight the different mechanisms by which the parasite interacts with its host to induce immune responses. All together, these data will allow us to have a better understanding of molecular mechansism of host-parasite interactions, which may shed lights on the development of an effective vaccine against .
由[寄生虫名称未给出]引起的感染对人类和动物而言仍然是一项重大的公共卫生挑战，可导致化脓性胆管炎、胆结石、胆囊炎、胆管纤维化，甚至胆管癌。然而，寄生虫所采用的策略以及宿主所使用的免疫机制尚未完全明确。随着技术的进步以及宿主 - 寄生虫相互作用知识的积累，许多针对肝吸虫的候选疫苗已通过不同策略进行了研究。在本综述中，我们深入探讨并分析了[寄生虫名称未给出]致病性所涉及的免疫机制。我们强调了寄生虫与宿主相互作用以诱导免疫反应的不同机制。总之，这些数据将使我们能够更好地理解宿主 - 寄生虫相互作用的分子机制，这可能为开发针对[寄生虫名称未给出]的有效疫苗提供线索。
