School of Life Sciences, University of Westminster, 115 New Cavendish Street, London W1W 6UW, UK.
J Clin Endocrinol Metab. 2012 Jan;97(1):155-62. doi: 10.1210/jc.2011-1843. Epub 2011 Oct 12.
Hypoxia and muscle contraction stimulate glucose transport in vitro. We have previously demonstrated that exercise and hypoxia have an additive effect on insulin sensitivity in type 2 diabetics.
Our objective was to examine the effects of three different hypoxic/exercise (Hy Ex) trials on glucose metabolism and insulin resistance in the 48 h after acute hypoxia in type 2 diabetics.
DESIGN, PARTICIPANTS, AND INTERVENTIONS: Eight male type 2 diabetics completed 60 min of hypoxic [mean (sem) O(2) = ∼14.7 (0.2)%] exercise at 90% of lactate threshold [Hy Ex(60); 49 (1) W]. Patients completed an additional two hypoxic trials of equal work, lasting 40 min [Hy Ex(40); 70 (1) W] and 20 min [Hy Ex(20); 140 (12) W].
Glucose rate of appearance and rate of disappearance were determined using the one-compartment minimal model. Homeostasis models of insulin resistance (HOMA(IR)), fasting insulin resistance index and β-cell function (HOMA(β-cell)) were calculated at 24 and 48 h after trials.
Peak glucose rate of appearance was highest during Hy Ex(20) [8.89 (0.56) mg/kg · min, P < 0.05]. HOMA(IR) and fasting insulin resistance index were improved in the 24 and 48 h after Hy Ex(60) and Hy Ex(40) (P < 0.05). HOMA(IR) decreased 24 h after Hy Ex(20) (P < 0.05) and returned to baseline values at 48 h.
Moderate-intensity exercise in hypoxia (Hy Ex(60) and Hy Ex(40)) stimulates acute- and moderate-term improvements in insulin sensitivity that were less apparent in Hy Ex(20). Results suggest that exercise duration and not total work completed has a greater influence on acute and moderate-term glucose control in type 2 diabetics.
缺氧和肌肉收缩可刺激体外葡萄糖转运。我们之前已经证明，运动和缺氧对 2 型糖尿病患者的胰岛素敏感性具有相加作用。
我们的目的是在 2 型糖尿病患者急性缺氧后 48 小时内，检查三种不同的低氧/运动（Hy Ex）试验对葡萄糖代谢和胰岛素抵抗的影响。
设计、参与者和干预措施：8 名男性 2 型糖尿病患者完成了 60 分钟的低氧（平均[SEM]O 2 = ∼14.7（0.2）%）运动，达到乳酸阈的 90%[Hy Ex（60）；49（1）W]。患者还完成了另外两个相同工作量的低氧试验，持续 40 分钟[Hy Ex（40）；70（1）W]和 20 分钟[Hy Ex（20）；140（12）W]。
使用一室最小模型确定葡萄糖出现率和消失率。在试验后 24 和 48 小时计算胰岛素抵抗的稳态模型（HOMA（IR））、空腹胰岛素抵抗指数和β细胞功能（HOMA（β细胞））。
Hy Ex（20）期间最高峰值葡萄糖出现率最高[8.89（0.56）mg/kg·min，P < 0.05]。Hy Ex（60）和 Hy Ex（40）后 24 和 48 小时 HOMA（IR）和空腹胰岛素抵抗指数均改善（P < 0.05）。Hy Ex（20）后 24 小时 HOMA（IR）下降（P < 0.05），48 小时恢复到基线值。
低氧运动（Hy Ex（60）和 Hy Ex（40））刺激急性和中期胰岛素敏感性的改善，而在 Hy Ex（20）中则不太明显。结果表明，运动持续时间而不是完成的总工作量对 2 型糖尿病患者的急性和中期血糖控制有更大的影响。
