Välimäki Matti J, Arola Johanna
HYKS, Meilahden sairaala, endokrinologian klinikka PL 340, 00029 HUS.
Duodecim. 2011;127(15):1549-59.
Neuroendocrine tumors (NET) originate from hormone-producing cells and may appear in any organ. Approximately 230 NET tumors are detected in Finland annually. NET tumors of the digestive tract and the pancreas can be detected accidentally in emergency surgery, after years of abdominal symptoms, or based on symptoms caused by the hormones produced. Basic investigations include determination of 5-hydroxyindoleacetic acid in 24-hour urine sample and plasma chromogranin, as well as gamma-imaging of somatostatin receptors. A treatment plan is devised on the basis of the pathologic-anatomic classification of the tumor. Surgery and drug therapy are first-line treatments. Targeted radiation therapy has also appeared promising.
神经内分泌肿瘤（NET）起源于产生激素的细胞，可出现在任何器官。芬兰每年约检测到230例NET肿瘤。消化道和胰腺的NET肿瘤可在急诊手术中意外发现，或在出现多年腹部症状后，或根据所产生激素引起的症状检测到。基本检查包括测定24小时尿液样本中的5-羟吲哚乙酸和血浆嗜铬粒蛋白，以及生长抑素受体的γ显像。治疗方案根据肿瘤的病理-解剖分类制定。手术和药物治疗是一线治疗方法。靶向放射治疗也显示出前景。
