Department of Pediatrics, Division of Pediatric Immunology, Uludag University Medical Faculty, Bursa, Turkey.
J Investig Allergol Clin Immunol. 2011;21(6):480-3.
Complementary and alternative medicine (CAM) usage is a reality in patients with chronic diseases, but there are no data on CAM usage in immunodeficiency diseases necessitating intravenous immunoglobulin (IVIG) therapy.The aim of this study was to investigate the rate of CAM usage in patients with common variable immunodeficiency (CVID).
Forty-three patients (29 boys and 14 girls) with CVID and receiving IVIG every 3 weeks were included. Data were collected through a questionnaire completed by the parents. Those using treatments other than their medical therapies that were defined as CAM by the National Center for Complementary and Alternative Medicine were classified as CAM users.
The mean (SD) age at diagnosis was 7.56 (9.44) years (range, 6 months to 44 years) and the mean IVIG treatment duration was 6.02 (3.84) years (range, 1 to 20 years). Thirty-six (83.7%) of the 43 patients analyzed had used at least 1 CAM approach. The most common modalities were herbal medicines (65.1%), dietary supplements (62.8%), vitamins (46.5%), and religion (34.9%). Only 11% of those interviewed had informed their doctor that they were using CAM. The most common reason for CAM usage was the desire to improve body resistance. Eighteen parents (50%) claimed that their children had benefited from CAM.
Our findings reveal that there is a remarkably high tendency to use CAM in patients with CVID. Although no side effects were reported by the families, potential drug interactions should be considered.
在患有慢性疾病的患者中，补充和替代医学（CAM）的使用是一种现实，但在需要静脉注射免疫球蛋白（IVIG）治疗的免疫缺陷疾病中，关于 CAM 使用的数据尚不清楚。本研究的目的是调查常见可变免疫缺陷（CVID）患者中 CAM 使用的比率。
纳入 43 名接受每 3 周接受一次 IVIG 治疗的 CVID 患者（29 名男孩和 14 名女孩）。通过父母填写的问卷收集数据。将被国家补充和替代医学中心定义为 CAM 的除医疗疗法以外的治疗方法归类为 CAM 用户。
诊断时的平均（SD）年龄为 7.56（9.44）岁（范围，6 个月至 44 岁），IVIG 治疗持续时间的平均为 6.02（3.84）年（范围，1 至 20 年）。分析的 43 名患者中有 36 名（83.7%）至少使用了 1 种 CAM 方法。最常见的方式是草药（65.1%）、膳食补充剂（62.8%）、维生素（46.5%）和宗教（34.9%）。只有 11%的受访者告知医生他们正在使用 CAM。使用 CAM 的最常见原因是希望提高身体抵抗力。18 名家长（50%）声称他们的孩子从 CAM 中受益。
我们的发现表明，CVID 患者使用 CAM 的倾向非常高。尽管家庭没有报告任何副作用，但应考虑潜在的药物相互作用。
