Division of Rheumatology and Clinical Immunology, University Hospital Würzburg, Oberdürrbacher Str. 6, 97080, Würzburg, Germany.
Institute for Hygiene and Microbiology, University of Würzburg, Josef-Schneider-Straße 2/E1, 97080, Würzburg, Germany.
J Clin Immunol. 2021 Apr;41(3):585-594. doi: 10.1007/s10875-020-00955-8. Epub 2021 Jan 6.
The term complementary and alternative medicine (CAM) describes a broad spectrum of health care practices that are not an integral part of the conventional health care system. Many patients worldwide use CAM on their own initiative, often in combination with their conventional medical therapy. CAM use is attractive especially to patients with primary immunodeficiency, since they suffer from frequent infections and autoimmunity. Those are frequently addressed by CAM providers. The aim of this multicentric study was to collect information on the use of CAM by these patients and to define characteristics that are associated with the use of CAM. A total of 101 patients with primary immunodeficiencies at German hospitals were surveyed on their CAM use (further 14 patients rejected to participate). Multiple psychological tests (MARS-D, WHO-5, PHQ9, EFQ) were conducted to investigate variations among personality traits associated with CAM use. Additionally, clinical and sociodemographic patient data was collected. A total of 72% of patients used CAM to treat their primary immunodeficiency. The three most frequently used methods were physical exercise or fitness training (65%), dietary supplements (58%), and homeopathy (49%). Most patients did not discuss CAM use with their doctors, mostly because they felt that there was no time for it. CAM plays an important role for patients with primary immunodeficiency in a high-resource health care setting such as Germany. In clinical practice, doctors should create a platform to discuss needs that go beyond conventional therapy.
补充和替代医学（CAM）一词描述了广泛的医疗保健实践，它们不是常规医疗保健系统的组成部分。全球许多患者自行使用 CAM，通常与传统的医疗疗法相结合。CAM 的使用对原发性免疫缺陷患者特别有吸引力，因为他们经常遭受感染和自身免疫。这些通常由 CAM 提供者解决。这项多中心研究的目的是收集有关这些患者使用 CAM 的信息，并确定与使用 CAM 相关的特征。对德国医院的 101 名原发性免疫缺陷患者进行了 CAM 使用情况调查（另有 14 名患者拒绝参与）。进行了多项心理测试（MARS-D、WHO-5、PHQ9、EFQ），以调查与 CAM 使用相关的人格特质变化。此外，还收集了临床和社会人口学患者数据。共有 72%的患者使用 CAM 治疗原发性免疫缺陷。使用最多的三种方法是体育锻炼或健身训练（65%）、膳食补充剂（58%）和顺势疗法（49%）。大多数患者没有与医生讨论 CAM 的使用情况，主要是因为他们觉得没有时间讨论。在德国等高资源医疗保健环境中，CAM 对原发性免疫缺陷患者起着重要作用。在临床实践中，医生应该创造一个平台来讨论超越传统治疗的需求。
