Wareing Mark
Maternal and Fetal Health Research Centre, School of Biomedicine, The University of Manchester, Manchester, UK.
J Obstet Gynaecol Res. 2012 Jan;38(1):185-91. doi: 10.1111/j.1447-0756.2011.01666.x. Epub 2011 Oct 14.
The human fetoplacental vasculature has been suggested to be a low resistance/high flow system, but the mechanisms by which this state is achieved are unclear.
This study assessed the effects of intraluminal flow and local oxygenation on isolated human placental chorionic plate arteries and veins at term using pressure myography.
Chorionic plate arteries and veins exhibit myogenic tone. A small but significant arterial vasodilatation was observed following exposure to hypoxia; chorionic plate veins contracted to a similar hypoxic stimulus. Under physiological conditions of pressure and oxygenation, increased luminal flow induced contraction in both chorionic plate arteries and veins. [Correction added after online publication 15th November 2011: 'induced vasodilatation' has been changed to 'induced contraction']
Human fetoplacental vascular tone can be manipulated by local physical factors.
有人提出人类胎儿胎盘血管系统是一个低阻力/高流量系统，但实现这种状态的机制尚不清楚。
本研究使用压力肌动描记法评估足月时管腔内血流和局部氧合对分离的人胎盘绒毛板动脉和静脉的影响。
绒毛板动脉和静脉表现出肌源性张力。暴露于低氧环境后观察到动脉有轻微但显著的血管舒张；绒毛板静脉对类似的低氧刺激产生收缩。在压力和氧合的生理条件下，管腔内血流增加会导致绒毛板动脉和静脉都发生收缩。[2011年11月15日在线发表后添加的更正：“导致血管舒张”已改为“导致收缩”]
人类胎儿胎盘血管张力可受局部物理因素调控。
