Dickison Philippa, Christou Elizabeth, Wargon Orli
Department of Dermatology, Sydney Children's Hospital, Randwick, Australia.
University of New South Wales, Sydney, Australia.
Pediatr Dermatol. 2011 Nov-Dec;28(6):663-669. doi: 10.1111/j.1525-1470.2011.01568.x. Epub 2011 Oct 13.
Infantile hemangiomas (IHs) are the most common tumor of infancy and have been estimated to occur in 4% of infants. Only two previous incidence studies of IH in a healthy population have been published, and both of these were performed in the first week of life. The objective was to identify the incidence of IH in an Australian neonatal population and characterize the risk factors. All women who presented to the postnatal ward in a 200-bed maternity hospital were asked to complete a questionnaire. Details of maternal history and birth details were recorded. Two follow-up emails 3 and 6 weeks after discharge were sent to all mothers who consented, asking if their baby had developed an IH. Babies reported to have an IH were seen in clinic to confirm the diagnosis. Details were collected from 1,034 mothers of 1,065 babies; 28 (2.6%) of the infants developed IH. Babies that developed IH were more likely to be female (p < 0.001), have a low birth weight (p = 0.020), be born at a gestational age of <37 weeks (p = 0.005), and be conceived through in vitro fertilization (IVF) (p = 0.001) than those who did not. The incidence of IH at 6 weeks of life was 2.6%.
婴儿血管瘤（IHs）是婴儿期最常见的肿瘤，据估计，4%的婴儿会发生该疾病。此前仅有两项关于健康人群中婴儿血管瘤发病率的研究发表，且这两项研究均在出生后第一周进行。本研究的目的是确定澳大利亚新生儿群体中婴儿血管瘤的发病率，并对风险因素进行特征分析。所有入住一家拥有200张床位的妇产医院产后病房的女性均被要求填写一份问卷。记录产妇病史和出生详情。在出院后3周和6周向所有同意参与的母亲发送两封随访电子邮件，询问其婴儿是否患上婴儿血管瘤。报告患有婴儿血管瘤的婴儿会被安排到门诊进行诊断确认。收集了1065名婴儿的1034名母亲的详细信息；其中28名（2.6%）婴儿患上了婴儿血管瘤。与未患婴儿血管瘤的婴儿相比，患上该病的婴儿更有可能为女性（p < 0.001）、出生体重低（p = 0.020）、孕周<37周（p = 0.005）以及通过体外受精（IVF）受孕（p = 0.001）。出生6周时婴儿血管瘤的发病率为2.6%。
