Exp Dermatol. 2011 Dec;20(12):1017-20. doi: 10.1111/j.1600-0625.2011.01361.x. Epub 2011 Oct 13.
Primary hyperhidrosis is characterized by excessive sweating in palmar, plantar and axillary body regions. Gland hypertrophy and the existence of a third type of sweat gland, the apoeccrine gland, with high fluid transporting capabilities have been suggested as possible causes. This study investigated whether sweat glands were hypertrophied in axillary hyperhidrotic patients and if mechanisms associated with fluid transport were found in all types of axillary sweat glands. The occurrence of apoeccrine sweat glands was also investigated. Axillary skin biopsies from control and hyperhidrosis patients were examined using immunohistochemistry, image analysis and immunofluorescence microscopy. Results showed that glands were not hypertrophied and that only the clear cells in the eccrine glands expressed proteins associated with fluid transport. There was no evidence of the presence of apoeccrine glands in the tissues investigated. Preliminary findings suggest the eccrine gland secretory clear cell as the main source of fluid transport in hyperhidrosis.
原发性多汗症的特征是手掌、足底和腋窝身体部位过度出汗。腺体肥大和存在第三种汗腺，即顶泌汗腺，具有高的流体输送能力，被认为是可能的原因。本研究调查了腋窝多汗症患者的汗腺是否肥大，以及所有类型的腋窝汗腺是否存在与流体输送相关的机制。还研究了顶泌汗腺的发生情况。使用免疫组织化学、图像分析和免疫荧光显微镜检查了来自对照和多汗症患者的腋窝皮肤活检。结果表明，腺体没有肥大，只有汗管的透明细胞表达与流体输送相关的蛋白质。在所研究的组织中没有发现顶泌汗腺的存在。初步研究结果表明，汗腺分泌的透明细胞是多汗症中流体输送的主要来源。
