Department of Pediatrics, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands.
Prostaglandins Leukot Essent Fatty Acids. 2011 Dec;85(6):311-6. doi: 10.1016/j.plefa.2011.09.005. Epub 2011 Oct 12.
Preterms need supplementation with docosahexaenoic (DHA) and arachidonic (AA) acids to prevent steep postnatal declines. Associations between growth and erythrocyte (RBC) DHA and AA were studied in 139 preterms (51% male, gestational age 30.3±1.5 weeks, birth weight 1341±288g) fed human milk with breast milk fortifier or preterm formula until term, followed by postdischarge formula (PDF; n=52, 0.4% DHA, 0.4% AA), term formula (TF; n=41, 0.2% DHA, 0.2% AA), or human milk (HM; n=46). At six months, PDF resulted in higher RBC-DHA than TF and HM, while RBC-AA was higher than TF, but similar to HM. There were no between-group differences in growth between term and six months. RHC-DHA related positively with gain in weight and length and negatively with gain in head circumference. RBC-AA related positively with gain in head circumference and negatively with gain in weight and length. In conclusion, PDF with higher DHA and AA than TF may promote postnatal growth of preterms.
早产儿需要补充二十二碳六烯酸（DHA）和花生四烯酸（AA），以防止出生后迅速下降。本研究旨在探讨 139 例早产儿（男婴占 51%，胎龄 30.3±1.5 周，出生体重 1341±288g）在接受母乳强化剂或早产儿配方奶喂养至足月（52 例喂养 PDF[含 0.4% DHA 和 0.4% AA]，41 例喂养 TF[含 0.2% DHA 和 0.2% AA]，46 例喂养 HM[含 0.2% DHA 和 0.2% AA]），随后转为出院后配方奶（PDF）、普通配方奶（TF）或人乳（HM）后的生长与红细胞（RBC）中 DHA 和 AA 的关系。6 月龄时，PDF 组 RBC-DHA 高于 TF 组和 HM 组，而 RBC-AA 高于 TF 组，但与 HM 组无差异。各配方组间在纠正胎龄 6 月龄的体重、身长和头围增长率方面均无差异。RBC-DHA 与体重、身长增长率呈正相关，与头围增长率呈负相关。RBC-AA 与头围增长率呈正相关，与体重、身长增长率呈负相关。综上，与 TF 相比，富含 DHA 和 AA 的 PDF 可能促进早产儿的生长。
