Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 1, 3584 CL Utrecht, The Netherlands.
Vet Parasitol. 2012 Apr 30;185(2-4):355-8. doi: 10.1016/j.vetpar.2011.09.028. Epub 2011 Sep 28.
A study was conducted to evaluate the occurrence of resistance against, in particular, ivermectin in cyathostomins in the Netherlands. Seventy horse farms were visited between October 2007 and November 2009. In initial screening, faecal samples were collected 2 weeks after deworming with either ivermectin, moxidectin or doramectin. Pooled faecal samples from a maximum of 10 horses were examined for worm eggs using a modified McMaster technique and for worm larvae after faecal larval cultures. In total 931 horses were involved. On 15 of 70 farms eggs and/or larvae were found. On 8 of these 15 farms a FECRT with ivermectin was performed on 43 horses. Efficacy of ivermectin against cyathostomins of 93% was found in one animal on one farm. Additionally, the strategies and efforts of the horse owners to control cyathostomins, as well as risk factors for the development of macrocyclic lactone resistance were evaluated with a questionnaire. Strikingly, many responders indicated that the control of cyathostomins in horses is achieved through very frequent deworming. Fourteen percent of these owners deworm seven times per year or more. On 34% of the 70 farms treatment was repeated within the Egg Reappearance Period of a product.
一项研究评估了荷兰旋毛虫对伊维菌素的耐药性。2007 年 10 月至 2009 年 11 月期间，研究人员访问了 70 个马场。在初步筛查中，在使用伊维菌素、莫昔克丁或多拉菌素驱虫后 2 周收集粪便样本。使用改良的麦克马斯特技术，对最大 10 匹马的粪便样本进行混合，检查虫卵，并进行粪便幼虫培养，以检查幼虫。共有 931 匹马参与了研究。在 70 个农场中的 15 个农场发现了虫卵和/或幼虫。在这 15 个农场中的 8 个农场，对 43 匹马进行了伊维菌素的 FECRT。在一个农场的一只动物中发现伊维菌素对旋毛虫的疗效为 93%。此外，还通过问卷调查评估了马主控制旋毛虫的策略和努力，以及大环内酯类耐药性发展的风险因素。引人注目的是，许多应答者表示，通过频繁驱虫可以控制马的旋毛虫。其中 14%的马主每年驱虫 7 次或更多次。在 70 个农场中的 34%，产品的虫卵重现期内重复了治疗。
