Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
J Neuroimmunol. 2011 Dec 15;240-241:74-8. doi: 10.1016/j.jneuroim.2011.09.004. Epub 2011 Oct 11.
Campylobacter jejuni enteritis is frequently associated with an axonal form of Guillain-Barré syndrome (GBS) and C. jejuni DNA-binding protein from starved cells (C-Dps) induces paranodal myelin detachment and axonal degeneration through binding with sulfatide in vivo. Here we investigated the invasion of C-Dps into hosts with C. jejuni-related GBS. Our analyses of patient sera found that both C-Dps and anti-C-Dps antibodies were most commonly detected in sera from C. jejuni-related GBS patients (5/27, 14.8% and 15/24, 62.5%; respectively). These findings suggest that C-Dps invades the host and may potentially contribute to the peripheral nerve damage in C. jejuni-related GBS.
空肠弯曲菌肠炎常与格林-巴利综合征（GBS）的轴索性形式相关，且空肠弯曲菌饥饿细胞 DNA 结合蛋白（C-Dps）通过与体内神经节苷脂结合诱导连接蛋白脱离和轴索变性。在此，我们研究了 C-Dps 对与空肠弯曲菌相关的 GBS 患者的侵袭情况。我们对患者血清的分析发现，C-Dps 和抗 C-Dps 抗体在与空肠弯曲菌相关的 GBS 患者血清中最常见（5/27，14.8%和 15/24，62.5%）。这些发现表明 C-Dps 入侵宿主，并可能导致与空肠弯曲菌相关的 GBS 中的周围神经损伤。
