Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, People's Republic of China.
Br J Nutr. 2012 Jul 14;108(1):57-61. doi: 10.1017/S0007114511005289.
The aims of the present study were to examine the serum amino acid profiles in obese and non-obese women and investigate the relationships between the serum amino acids and inflammation and oxidative stress in a human case-control study. Serum amino acids, inflammatory biomarkers (C-reactive protein and IL-6) and oxidative biomarkers (superoxide dismutase, malondialdehyde and glutathione peroxidase) were measured and compared in 235 obese women and 217 non-obese controls. The relationships between serum amino acids and inflammatory and oxidative biomarkers were examined using multiple linear regression. Among the amino acids determined, serum histidine, arginine, threonine, glycine, lysine and serine were found to be significantly lower in obese women as compared to non-obese controls (P < 0·001). The difference was the greatest for histidine (P < 0·001). In obese women, both histidine and arginine were negatively associated with inflammation and oxidative stress. In non-obese controls, histidine was negatively associated with oxidative stress. The findings in this study indicate that the metabolism of amino acids is abnormal in obese women in whom histidine and arginine have close relationships with inflammation and oxidative stress.
本研究旨在通过病例对照研究，检测肥胖和非肥胖女性的血清氨基酸谱，并探讨血清氨基酸与炎症和氧化应激之间的关系。共检测了 235 名肥胖女性和 217 名非肥胖对照者的血清氨基酸、炎症生物标志物（C 反应蛋白和白细胞介素 6）和氧化生物标志物（超氧化物歧化酶、丙二醛和谷胱甘肽过氧化物酶），并对其进行了比较。采用多元线性回归分析了血清氨基酸与炎症和氧化生物标志物之间的关系。与非肥胖对照组相比，肥胖女性的血清组氨酸、精氨酸、苏氨酸、甘氨酸、赖氨酸和丝氨酸显著降低（P<0·001）。其中组氨酸的差异最大（P<0·001）。在肥胖女性中，组氨酸和精氨酸与炎症和氧化应激呈负相关。在非肥胖对照组中，组氨酸与氧化应激呈负相关。本研究结果表明，肥胖女性的氨基酸代谢异常，组氨酸和精氨酸与炎症和氧化应激密切相关。
