Department of Medicine, Monash University, Melbourne Victoria, 3004, Australia.
Clin Immunol. 2011 Dec;141(3):253-67. doi: 10.1016/j.clim.2011.09.002. Epub 2011 Sep 17.
Functional naïve T-cells are critical for an effective immune response to multiple pathogens. HIV leads to a significant reduction in CD4+ naïve T-cell number and impaired function and there is incomplete recovery following combination antiretroviral therapy (cART). Here we review the basic homeostatic mechanisms that maintain naïve CD4+ T-cells and discuss recent developments in understanding the impact of HIV infection on naïve CD4+ T-cells. Finally we review therapeutic interventions in HIV-infected individuals aimed at specifically enhancing recovery of naïve CD4+ T-cells.
功能性幼稚 T 细胞对于针对多种病原体的有效免疫反应至关重要。HIV 会导致 CD4+幼稚 T 细胞数量显著减少，功能受损，并且在联合抗逆转录病毒治疗（cART）后无法完全恢复。在这里，我们回顾了维持幼稚 CD4+T 细胞的基本动态平衡机制，并讨论了最近对 HIV 感染对幼稚 CD4+T 细胞影响的理解的发展。最后，我们回顾了针对 HIV 感染者的旨在特异性增强幼稚 CD4+T 细胞恢复的治疗干预措施。
