Neurology, Clinique St Pierre, B-1340 Ottignies, Belgium.
Seizure. 2012 Jan;21(1):51-4. doi: 10.1016/j.seizure.2011.09.006. Epub 2011 Oct 12.
We report a case of Takotsubo syndrome after epilepsy, and review the literature. We identified 59 cases of Takotsubo syndrome after focal or generalised epilepsy. As in Takotsubo syndrome in general, the patients were mostly female (84%), with a mean age of 63 years, and the evolution was generally favourable. There was one death and one stroke, and 4 cases were of relapsing Takotsubo after a new seizure. Takotsubo syndrome may induce cardiac arrhythmias. A near-SUDEP (sudden unexplained death in epilepsy) was reported in one patient. Animal models of SUDEP have shown similar cardiac lesions to those seen in Takotsubo syndrome, and strengthen the hypothesis of a link between these conditions. Takotsubo syndrome after epilepsy may be relatively common; we suggest measurement of serum troponin levels in high-risk patients and cardiac follow-up.
我们报告了一例癫痫后心尖球囊样综合征病例，并复习了相关文献。我们共发现 59 例局灶性或全身性癫痫后心尖球囊样综合征病例。与一般的心尖球囊样综合征患者一样，这些患者多为女性（84%），平均年龄 63 岁，病情总体预后良好。有 1 例死亡和 1 例卒中，4 例患者在新的癫痫发作后出现复发性心尖球囊样综合征。心尖球囊样综合征可引发心律失常。有 1 例患者出现接近癫痫猝死（sudden unexplained death in epilepsy，SUDEP）的情况。SUDEP 的动物模型显示出与心尖球囊样综合征相似的心脏病变，这进一步支持了这两种疾病之间存在关联的假说。癫痫后心尖球囊样综合征可能较为常见；我们建议对高危患者进行血清肌钙蛋白水平检测，并进行心脏随访。
