核架构：层粘连蛋白病的细胞生物学。
Nuclear architecture: the cell biology of a laminopathy.
机构信息
Department of Molecular Biosciences, Northwestern University, Hogan 2100, Evanston, IL 60201, USA.
出版信息
Curr Biol. 2011 Oct 11;21(19):R807-9. doi: 10.1016/j.cub.2011.09.006.
Abstract
Lamin mutations cause muscular dystrophies, but the mechanism is unclear. A new study shows that lamin mutant worms display muscle-specific defects linked to altered subnuclear localization of heterochromatin, leading to altered gene expression.
摘要
核纤层蛋白突变会导致肌肉疾病，但具体机制尚不清楚。一项新的研究表明，核纤层蛋白突变的线虫表现出与异染色质亚核定位改变相关的肌肉特异性缺陷，进而导致基因表达改变。
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本文引用的文献
1
An EDMD mutation in C. elegans lamin blocks muscle-specific gene relocation and compromises muscle integrity.秀丽隐杆线虫中 EDMD 突变的核纤层蛋白阻碍肌肉特异性基因重定位并损害肌肉完整性。
Curr Biol. 2011 Oct 11;21(19):1603-14. doi: 10.1016/j.cub.2011.08.030. Epub 2011 Sep 29.
2
Caenorhabditis elegans chromosome arms are anchored to the nuclear membrane via discontinuous association with LEM-2.秀丽隐杆线虫染色体臂通过与 LEM-2 的不连续结合锚定在核膜上。
Genome Biol. 2010;11(12):R120. doi: 10.1186/gb-2010-11-12-r120. Epub 2010 Dec 23.
3
Nuclear lamins.核纤层蛋白。
Cold Spring Harb Perspect Biol. 2010 Nov;2(11):a000547. doi: 10.1101/cshperspect.a000547. Epub 2010 Sep 8.
4
Molecular maps of the reorganization of genome-nuclear lamina interactions during differentiation.分子图谱显示基因组-核层粘连蛋白相互作用在分化过程中的重排。
Mol Cell. 2010 May 28;38(4):603-13. doi: 10.1016/j.molcel.2010.03.016.
5
The spatial dynamics of tissue-specific promoters during C. elegans development.秀丽隐杆线虫发育过程中组织特异性启动子的空间动态。
Genes Dev. 2010 Apr 15;24(8):766-82. doi: 10.1101/gad.559610.
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Diseases of the nuclear envelope.核膜疾病。
Cold Spring Harb Perspect Biol. 2010 Feb;2(2):a000760. doi: 10.1101/cshperspect.a000760.
7
Domain organization of human chromosomes revealed by mapping of nuclear lamina interactions.通过核纤层相互作用图谱揭示的人类染色体结构域组织
Nature. 2008 Jun 12;453(7197):948-51. doi: 10.1038/nature06947. Epub 2008 May 7.
8
Recruitment to the nuclear periphery can alter expression of genes in human cells.募集至核周可改变人类细胞中的基因表达。
PLoS Genet. 2008 Mar 21;4(3):e1000039. doi: 10.1371/journal.pgen.1000039.
9
Transcriptional repression mediated by repositioning of genes to the nuclear lamina.基因重新定位至核纤层介导的转录抑制。
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10
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Muscle Nerve. 2003 Apr;27(4):393-406. doi: 10.1002/mus.10302.
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