核纤层蛋白。
Nuclear lamins.
机构信息
Department of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA.
出版信息
Cold Spring Harb Perspect Biol. 2010 Nov;2(11):a000547. doi: 10.1101/cshperspect.a000547. Epub 2010 Sep 8.
Abstract
The nuclear lamins are type V intermediate filament proteins that are critically important for the structural properties of the nucleus. In addition, they are involved in the regulation of numerous nuclear processes, including DNA replication, transcription and chromatin organization. The developmentally regulated expression of lamins suggests that they are involved in cellular differentiation. Their assembly dynamic properties throughout the cell cycle, particularly in mitosis, are influenced by posttranslational modifications. Lamins may regulate nuclear functions by direct interactions with chromatin and determining the spatial organization of chromosomes within the nuclear space. They may also regulate chromatin functions by interacting with factors that epigenetically modify the chromatin or directly regulate replication or transcription.
摘要
核纤层蛋白是 V 型中间丝蛋白，对核的结构特性至关重要。此外，它们还参与许多核过程的调节，包括 DNA 复制、转录和染色质组织。核纤层蛋白的发育调控表达表明它们参与了细胞分化。它们在整个细胞周期中的组装动态特性，特别是在有丝分裂中，受到翻译后修饰的影响。核纤层蛋白可以通过与染色质的直接相互作用以及确定染色体在核空间内的空间组织来调节核功能。它们还可以通过与表观遗传修饰染色质或直接调节复制或转录的因子相互作用来调节染色质功能。
相似文献
1
Nuclear lamins.核纤层蛋白。
Cold Spring Harb Perspect Biol. 2010 Nov;2(11):a000547. doi: 10.1101/cshperspect.a000547. Epub 2010 Sep 8.
2
Review: the dynamics of the nuclear lamins during the cell cycle-- relationship between structure and function.综述：细胞周期中核纤层蛋白的动态变化——结构与功能的关系
J Struct Biol. 2000 Apr;129(2-3):324-34. doi: 10.1006/jsbi.2000.4251.
3
Nuclear lamins in cell regulation and disease.细胞调控与疾病中的核纤层蛋白。
Cold Spring Harb Symp Quant Biol. 2010;75:525-31. doi: 10.1101/sqb.2010.75.045. Epub 2011 Apr 5.
4
Review: nuclear lamins--structural proteins with fundamental functions.综述：核纤层蛋白——具有基本功能的结构蛋白。
J Struct Biol. 2000 Apr;129(2-3):313-23. doi: 10.1006/jsbi.2000.4216.
5
Nuclear lamins: major factors in the structural organization and function of the nucleus and chromatin.核纤层蛋白：细胞核和染色质结构组织与功能中的主要因素。
Genes Dev. 2008 Apr 1;22(7):832-53. doi: 10.1101/gad.1652708.
6
The nucleoskeleton: lamins and actin are major players in essential nuclear functions.核骨架：核纤层蛋白和肌动蛋白是核基本功能的主要参与者。
Curr Opin Cell Biol. 2003 Jun;15(3):358-66. doi: 10.1016/s0955-0674(03)00050-4.
7
Assembly and cell cycle dynamics of the nuclear lamina.核纤层的组装与细胞周期动力学
Semin Cell Biol. 1992 Aug;3(4):245-53. doi: 10.1016/1043-4682(92)90026-r.
8
Laminopathies: multiple disorders arising from defects in nuclear architecture.核纤层蛋白病：由核结构缺陷引发的多种病症。
J Biosci. 2006 Sep;31(3):405-21. doi: 10.1007/BF02704113.
9
Lamins: building blocks or regulators of gene expression?核纤层蛋白：基因表达的构建模块还是调节因子？
Nat Rev Mol Cell Biol. 2002 Nov;3(11):848-58. doi: 10.1038/nrm950.
10
Role of A- and B-type lamins in nuclear structure-function relationships.A 型和 B 型核纤层蛋白在核结构-功能关系中的作用。
Biol Cell. 2021 Jul;113(7):295-310. doi: 10.1111/boc.202000160. Epub 2021 Mar 12.
引用本文的文献
1
as a Model for Studying the Roles of Lamins in Normal Tissues and Laminopathies.作为研究核纤层蛋白在正常组织和核纤层蛋白病中作用的模型。
Cells. 2025 Aug 22;14(17):1303. doi: 10.3390/cells14171303.
2
Lamin A/C promotes HBV transcription by modulating histone modification associated with cccDNA minichromosome in an HBx-dependent manner.核纤层蛋白A/C以HBx依赖的方式通过调节与cccDNA微型染色体相关的组蛋白修饰来促进乙肝病毒转录。
Virol J. 2025 Jun 11;22(1):189. doi: 10.1186/s12985-025-02820-9.
3
Early dynamics of chromatin decompaction drive nuclear stiffening.染色质解压缩的早期动态变化驱动细胞核变硬。
Proc Natl Acad Sci U S A. 2025 Jun 10;122(23):e2508415122. doi: 10.1073/pnas.2508415122. Epub 2025 Jun 2.
4
MyoD1 localization at the nuclear periphery is mediated by association of WFS1 with active enhancers.肌分化蛋白1（MyoD1）在核周的定位是由WFS1与活性增强子的结合介导的。
Nat Commun. 2025 Mar 17;16(1):2614. doi: 10.1038/s41467-025-57758-x.
5
Nuclear Structure, Size Regulation, and Role in Cell Migration.核结构、大小调控及其在细胞迁移中的作用。
Cells. 2024 Dec 23;13(24):2130. doi: 10.3390/cells13242130.
6
Normal Bone Matrix Mineralization but Altered Growth Plate Morphology in the Lmna Mouse Model of Progeria.早衰症的Lmna小鼠模型中骨基质矿化正常但生长板形态改变
Aging Dis. 2024 Nov 4;16(5):3204-3218. doi: 10.14336/AD.2024.1094.
7
Perinuclear assembly of vimentin intermediate filaments induces cancer cell nuclear dysmorphia.波形蛋白中间丝的核周组装诱导癌细胞核异型性。
J Biol Chem. 2024 Dec;300(12):107981. doi: 10.1016/j.jbc.2024.107981. Epub 2024 Nov 13.
8
Structural Diversity and Distribution of Nuclear Matrix Constituent Protein Class Nuclear Lamina Proteins in Streptophytic Algae.光合同源藻类核基质组成蛋白核纤层蛋白的结构多样性与分布。
Genome Biol Evol. 2024 Nov 1;16(11). doi: 10.1093/gbe/evae244.
9
-Related Dilated Cardiomyopathy: Single-Cell Transcriptomics during Patient-Derived iPSC Differentiation Support Cell Type and Lineage-Specific Dysregulation of Gene Expression and Development for Cardiomyocytes and Epicardium-Derived Cells with Lamin A/C Haploinsufficiency.相关扩张型心肌病：患者来源 iPSC 分化过程中的单细胞转录组学研究支持肌细胞和心外膜衍生细胞的基因表达和发育的细胞类型和谱系特异性失调，伴有核纤层蛋白 A/C 单倍不足。
Cells. 2024 Sep 3;13(17):1479. doi: 10.3390/cells13171479.
10
-SLENP: A Chemical Genetics Strategy To Selectively Label Existing Proteins and Newly Synthesized Proteins.-SLENP：一种用于选择性标记现有蛋白质和新合成蛋白质的化学遗传学策略。
JACS Au. 2024 Jul 25;4(8):3146-3156. doi: 10.1021/jacsau.4c00461. eCollection 2024 Aug 26.
本文引用的文献
1
Role of A-type lamins in signaling, transcription, and chromatin organization.A型核纤层蛋白在信号转导、转录和染色质组织中的作用。
J Cell Biol. 2009 Dec 28;187(7):945-57. doi: 10.1083/jcb.200904124.
2
A progeria mutation reveals functions for lamin A in nuclear assembly, architecture, and chromosome organization.早衰症突变揭示了核组装、结构和染色体组织中核纤层蛋白 A 的功能。
Proc Natl Acad Sci U S A. 2009 Dec 8;106(49):20788-93. doi: 10.1073/pnas.0911895106. Epub 2009 Nov 19.
3
Nuclei take a position: managing nuclear location.细胞核定位：调控细胞核位置
Dev Cell. 2009 Nov;17(5):587-97. doi: 10.1016/j.devcel.2009.10.018.
4
Loss of A-type lamins and genomic instability.A 型核纤层蛋白的丧失与基因组不稳定性。
Cell Cycle. 2009 Dec;8(23):3860-5. doi: 10.4161/cc.8.23.10092. Epub 2009 Dec 15.
5
Ageing-related chromatin defects through loss of the NURD complex.由于核小体重塑去乙酰化酶复合物缺失导致的与衰老相关的染色质缺陷。
Nat Cell Biol. 2009 Oct;11(10):1261-7. doi: 10.1038/ncb1971. Epub 2009 Sep 6.
6
Identification of a perinuclear positioning element in human subtelomeres that requires A-type lamins and CTCF.在人类亚端粒中鉴定出一种需要A型核纤层蛋白和CTCF的核周定位元件。
EMBO J. 2009 Aug 19;28(16):2428-36. doi: 10.1038/emboj.2009.201. Epub 2009 Jul 30.
7
Novel roles for A-type lamins in telomere biology and the DNA damage response pathway.A型核纤层蛋白在端粒生物学和DNA损伤反应途径中的新作用。
EMBO J. 2009 Aug 19;28(16):2414-27. doi: 10.1038/emboj.2009.196. Epub 2009 Jul 23.
8
Impaired nuclear functions lead to increased senescence and inefficient differentiation in human myoblasts with a dominant p.R545C mutation in the LMNA gene.在LMNA基因中存在显性p.R545C突变的人类成肌细胞中，核功能受损会导致衰老加剧和分化效率低下。
Eur J Cell Biol. 2009 Oct;88(10):593-608. doi: 10.1016/j.ejcb.2009.06.002. Epub 2009 Jul 8.
9
Phosphorylation-dependent binding of human transcription factor MOK2 to lamin A/C.人类转录因子MOK2与核纤层蛋白A/C的磷酸化依赖性结合。
FEBS J. 2009 Jun;276(11):3137-47. doi: 10.1111/j.1742-4658.2009.07032.x. Epub 2009 Apr 23.
10
The posttranslational processing of prelamin A and disease.前体核纤层蛋白A的翻译后加工与疾病
Annu Rev Genomics Hum Genet. 2009;10:153-74. doi: 10.1146/annurev-genom-082908-150150.
Zotero 插件