Department of Biochemistry and Huntsman Cancer Institute, University of Utah, School of Medicine, Salt Lake City, UT 84112, USA.
Curr Biol. 2011 Oct 11;21(19):R811-3. doi: 10.1016/j.cub.2011.08.045.
Proteins involved in membrane traffic must distinguish between different classes of vesicles. New work now shows that α-synuclein and ALPS motifs represent two extreme types of amphipathic helix that are tuned to detect both the curvature of transport vesicles as well as their bulk lipid content.
参与膜运输的蛋白质必须区分不同类型的囊泡。现在的新工作表明，α-突触核蛋白和 ALPS 基序代表了两种极端类型的两亲性螺旋，它们能够检测运输囊泡的曲率以及它们的总体脂质含量。
