膜运输：用不同的化学性质解码囊泡身份。

Membrane trafficking: decoding vesicle identity with contrasting chemistries.

机构信息

Department of Biochemistry and Huntsman Cancer Institute, University of Utah, School of Medicine, Salt Lake City, UT 84112, USA.

出版信息

Curr Biol. 2011 Oct 11;21(19):R811-3. doi: 10.1016/j.cub.2011.08.045.

DOI:10.1016/j.cub.2011.08.045

PMID:21996503

Abstract

Proteins involved in membrane traffic must distinguish between different classes of vesicles. New work now shows that α-synuclein and ALPS motifs represent two extreme types of amphipathic helix that are tuned to detect both the curvature of transport vesicles as well as their bulk lipid content.

摘要

参与膜运输的蛋白质必须区分不同类型的囊泡。现在的新工作表明，α-突触核蛋白和 ALPS 基序代表了两种极端类型的两亲性螺旋，它们能够检测运输囊泡的曲率以及它们的总体脂质含量。