Wang Xiaomin, Fujimaki Makoto, Kato Takafumi, Nomura Ken-Ichi, Awazu Koichi, Ohki Yoshimichi
National Institute of Advanced Industrial Science and Technology (AIST), 1-1-1 Higashi, Tsukuba, Ibaraki 305-8562, Japan.
Opt Express. 2011 Oct 10;19(21):20205-13. doi: 10.1364/OE.19.020205.
Optical planar waveguide-mode sensor is a promising candidate for highly sensitive biosensing techniques in fields such as protein adsorption, receptor-ligand interaction and surface bacteria adhesion. To make the waveguide-mode sensor system more realistic, a spectral readout type waveguide sensor is proposed to take advantage of its high speed, compactness and low cost. Based on our previously proposed monolithic waveguide-mode sensor composed of a SiO2 waveguide layer and a single crystalline Si layer [1], the mechanism for achieving high sensitivity is revealed by numerical simulations. The optimal achievable sensitivities for a series of waveguide structures are summarized in a contour map, and they are found to be better than those of previously reported angle-scan type waveguide sensors.
光学平面波导模式传感器是蛋白质吸附、受体 - 配体相互作用和表面细菌粘附等领域高灵敏度生物传感技术的一个有前景的候选者。为了使波导模式传感器系统更具实用性，提出了一种光谱读出型波导传感器，以利用其高速、紧凑和低成本的特点。基于我们之前提出的由SiO2波导层和单晶硅层组成的单片波导模式传感器[1]，通过数值模拟揭示了实现高灵敏度的机制。一系列波导结构的最佳可实现灵敏度总结在等高线图中，发现它们优于先前报道的角度扫描型波导传感器。
