Doi T, Hattori M, Agodoa L Y, Sato T, Yoshida H, Striker L J, Striker G E
National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland.
Lab Invest. 1990 Aug;63(2):204-12.
The natural history of renal lesions in nonobese diabetic mice was assessed. This strain develops a spontaneous overt insulin-dependent diabetes that has a female predominance and an autoimmune pathogenesis. We compared mice that had a normal glucose tolerance test with mice that had a diabetes of 2 to 15 weeks' duration. The glomerular surface area was increased in all diabetic mice regardless of the duration of hyperglycemia. There was an increase in the albumin/creatinine ratio in the urine of diabetic mice. Finally, nonobese diabetic mice all showed mesangial sclerosis that was more pronounced in the diabetic mice. This suggests that this strain is susceptible to glomerulosclerosis and that the occurrence of hyperglycemia results in an increase of glomerular size, mesangial sclerosis, and proteinuria, soon after glycosuria is first demonstrated.
评估了非肥胖糖尿病小鼠肾脏病变的自然病程。该品系会自发发生明显的胰岛素依赖型糖尿病，女性发病率更高，且具有自身免疫发病机制。我们将葡萄糖耐量试验正常的小鼠与病程为2至15周的糖尿病小鼠进行了比较。无论高血糖持续时间如何，所有糖尿病小鼠的肾小球表面积均增加。糖尿病小鼠尿液中的白蛋白/肌酐比值升高。最后，非肥胖糖尿病小鼠均出现系膜硬化，在糖尿病小鼠中更为明显。这表明该品系易患肾小球硬化，且高血糖的出现会导致在首次出现糖尿后不久肾小球大小增加、系膜硬化和蛋白尿。
