Wehner H, Petri M
Pathol Res Pract. 1983 Mar;176(2-4):145-57. doi: 10.1016/S0344-0338(83)80006-5.
To detect structural glomerular alterations in the early stages of diabetes mellitus glomeruli from young streptozotocin diabetic rats were studied by light microscopy with morphometric methods 2, 8, 12 and 24 weeks after induction of diabetes. It was found that there is a marked increase in the percentage mesangial surface as compared with the control animals already two weeks after induction of diabetes. The relative mesangial surface fraction was greater in the diabetic animals than in the controls at all test times. It was also demonstrated that the endothelial cell count was reduced in the diabetic animals in the first few weeks of the study. High-grade glycosuria and proteinuria were likewise observed in the diabetic animals. Hence the mesangium appears to be one of the glomerular structures which shows the first changes in the initial stages of diabetes mellitus. Possibly the most likely cause of the changes based on the present study is the diabetic metabolic state (or the insulin deficiency).
为了检测糖尿病早期肾小球的结构改变，对年轻的链脲佐菌素诱导的糖尿病大鼠的肾小球进行了研究，在糖尿病诱导后的2、8、12和24周，采用形态计量学方法通过光学显微镜观察。结果发现，与对照动物相比，糖尿病诱导后仅两周，系膜表面积百分比就显著增加。在所有测试时间，糖尿病动物的相对系膜表面积分数均高于对照组。研究还表明，在研究的最初几周，糖尿病动物的内皮细胞计数减少。糖尿病动物同样出现了高度糖尿和蛋白尿。因此，系膜似乎是糖尿病早期出现最早变化的肾小球结构之一。根据本研究，这些变化最可能的原因可能是糖尿病代谢状态（或胰岛素缺乏）。
