Department of Internal Medicine 1, Shimane University Faculty of Medicine, 89-1 Enya-cho, Izumo 693-8501, Japan.
J Endocrinol Invest. 2012 May;35(5):469-72. doi: 10.3275/8033. Epub 2011 Oct 10.
Although accumulating evidence shows that aging hormones are involved in glucose metabolism, effects of glycemic control on serum IGF-I and DHEAS levels are still unclear.
To investigate the effects of glycemic control on these hormone levels, we conducted a 1-month longitudinal study of 49 Japanese patients with Type 2 diabetes mellitus. We measured serum levels of IGF-I and DHEA-S before and after 1-month glycemic control and analyzed the association of changes in IGF-I and DHEA-S with glycated hemoglobin (HbA1c).
HbA1c was decreased at 1 month with mean changes of -1.2% (p<0.001). Serum IGF-I was increased with mean changes of 11 ng/ml (p<0.05), while serum DHEA-S was decreased with mean changes of -19 μg/dl (p<0.05). Multiple regression analysis showed that changes in DHEA-S were inversely associated with changes in fasting plasma glucose (β=-0.36, p=0.027) and HbA1c (β=-0.33, p=0.028), while changes in IGF-I were not.
The present longitudinal study showed that intensive glycemic control for 1 month increased serum IGF-I level and decreased serum DHEA-S level in Japanese patients with poorly controlled Type 2 diabetes. Further studies are needed to clarify the hormonal changes in IGF-I and DHEA-S after intensive glycemic control would affect diabetic complications.
尽管越来越多的证据表明衰老激素参与了葡萄糖代谢，但血糖控制对血清 IGF-I 和 DHEAS 水平的影响仍不清楚。
为了研究血糖控制对这些激素水平的影响，我们对 49 例 2 型糖尿病日本患者进行了为期 1 个月的纵向研究。我们在 1 个月的血糖控制前后测量了血清 IGF-I 和 DHEA-S 水平，并分析了 IGF-I 和 DHEA-S 的变化与糖化血红蛋白（HbA1c）的关系。
HbA1c 在 1 个月时下降，平均变化为-1.2%（p<0.001）。血清 IGF-I 增加，平均变化为 11ng/ml（p<0.05），而血清 DHEA-S 减少，平均变化为-19μg/dl（p<0.05）。多元回归分析显示，DHEA-S 的变化与空腹血糖（β=-0.36，p=0.027）和 HbA1c（β=-0.33，p=0.028）的变化呈负相关，而 IGF-I 的变化则无相关性。
本纵向研究表明，1 个月的强化血糖控制可增加血糖控制不佳的 2 型糖尿病日本患者的血清 IGF-I 水平并降低血清 DHEA-S 水平。需要进一步研究以阐明 IGF-I 和 DHEA-S 在强化血糖控制后的激素变化是否会影响糖尿病并发症。
