Division of Neuroscience, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006, USA.
Exp Gerontol. 2013 Oct;48(10):1136-9. doi: 10.1016/j.exger.2013.01.001. Epub 2013 Jan 11.
The adrenal steroid, dehydroepiandrosterone sulfate (DHEAS), is generally regarded as being a reliable endocrine marker of aging, because in humans and nonhuman primates its circulating concentrations are very high during young adulthood, and the concentrations then decline markedly during aging. Despite promising results from early studies, we were recently surprised to find that caloric restriction (CR) did little to prevent or delay the decline of DHEAS concentrations in old rhesus macaques. Here we summarize the use of circulating DHEAS concentrations as a biomarker of aging in CR studies and suggest reasons for its limited value. Although DHEAS can reliably predict aging in animals maintained on a standard diet, dietary manipulations may affect liver enzymes involved in the metabolism of steroid hormones. Consequently, in CR studies the reliability of using DHEAS as a biomarker of aging may be compromised.
肾上腺类固醇脱氢表雄酮硫酸盐（DHEAS）通常被认为是衰老的可靠内分泌标志物，因为在人类和非人类灵长类动物中，其循环浓度在青年期非常高，然后在衰老过程中明显下降。尽管早期研究结果很有希望，但我们最近惊讶地发现，热量限制（CR）几乎不能防止或延缓老年恒河猴 DHEAS 浓度的下降。在这里，我们总结了循环 DHEAS 浓度作为 CR 研究中衰老生物标志物的使用，并提出了其有限价值的原因。尽管 DHEAS 可以可靠地预测标准饮食维持的动物的衰老，但饮食干预可能会影响参与类固醇激素代谢的肝脏酶。因此，在 CR 研究中，使用 DHEAS 作为衰老生物标志物的可靠性可能受到影响。
